No Evidence for Autoimmunity as a Major Cause of the Empty Sella Syndrome
| Autor: | C. Sanjeevi, K. Ericson, Olle Kämpe, A-L Hulting, Patricia Crock, Sophie Bensing, Fredrik Rorsman, Kerstin Brismar |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Adult
Pituitary gland Endocrinology Diabetes and Metabolism Autoimmunity Hypopituitarism medicine.disease_cause Empty sella syndrome Endocrinology Reference Values Thyroid peroxidase Immunopathology Internal Medicine medicine Humans Aged Autoantibodies Autoimmune disease biology business.industry Empty Sella Syndrome Autoantibody General Medicine Middle Aged medicine.disease medicine.anatomical_structure Pituitary Gland Immunology biology.protein business |
| Zdroj: | Experimental and Clinical Endocrinology & Diabetes. 112:231-235 |
| ISSN: | 1439-3646 0947-7349 |
| DOI: | 10.1055/s-2004-817968 |
| Popis: | Objective The cause of empty sella syndrome (ESS) remains largely unknown. We measured eleven organ-specific autoantibodies in serum in order to evaluate possible autoimmune components in ESS. Patients Thirty patients with ESS and 50 healthy blood donors participated in the study. Measurements Detection of pituitary autoantibodies was performed by immunoblotting with human pituitary cytosol as antigen. Thyroid peroxidase (TPO) and TSH receptor (TRAK) autoantibodies were analysed by radioimmunoassay. The remaining eight autoantibodies were detected by in vitro transcription and translation of the autoantigens and immunoprecipitation. Results The majority of the ESS patients (18/30) exhibited no immunoreactivity at all. None of the remaining 12 ESS patients reacted against more than one autoantigen. No immunoreactivity was found more frequently among ESS patients than healthy blood donors. Pituitary autoantibodies were not correlated to the ESS patients' pituitary function or sellar size, although the results indicated a tendency of increased autoimmunity in patients with hypopituitarism and normal sella size respectively. Conclusion Detection of autoantibodies is a valuable tool in the diagnostic work-up of autoimmune diseases. By analysing a large number of organ-specific autoantibodies we found no evidence of ESS being associated with any specific autoimmune disease. The pathogenesis of ESS is believed to be heterogeneous and our findings suggest autoimmune components to be of minor importance. In some selective cases, ESS in combination with hypopituitarism may be the result of an autoimmune disease in the pituitary gland but this needs further investigation. |
| Databáze: | OpenAIRE |
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