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Aim: To investigate the effect of metformin hydrochloride on carbohydrate metabolism in polycystic ovary syndrome, a clinical study was conducted in fifty infertile women with polycystic ovarian syndrome aged 20 to 40 years. Place and Duration: In the Pharmacology and Therapeutics Department and Gynecology and Obstetrics, Unit-I of Services Hospital, Lahore for six-months duration from March 2020 to August 2020. Methods: 50 females were enrolled and received a 500 mg metformin HCl tablet three times a day for a period of three months. Fasting serum glucose (FSG) and fasting serum insulin (FSI) were performed twice during the study period (day zero and day ninety) to evaluate the effects on carbohydrate metabolism. Results and Conclusions: Significant reductions in both FSG and FSI levels were found on day ninetie at P = 0.001. Metformin has been found to have a beneficial effect on carbohydrate metabolism in patients with polycystic ovary syndrome. This is because of the increased peripheral glucose uptake and utilization of metformin, which in turn increases insulin sensitivity and reduces insulin resistance in these patients. Key words: polycystic ovary syndrome, carbohydrate metabolism, fasting serum glucose, fasting serum insulin, metformin hydrochloride. |
