The Val66Met Polymorphism at the BDNF Gene does not Influence Wisconsin Card Sorting Test Results in Children and Adolescents with Bipolar Disorder
Autor: | Mara H. Hutz, Gabriel Ferreira Pheula, Silzá Tramontina, Angélica Salatino-Oliveira, Roberta Paula Schell Coelho, Julio Bernardi, Thamis Aline Zeni, Luis Augusto Rohde, Cristian Patrick Zeni, Ursula Maldaner, Talita Lopes Silva |
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Rok vydání: | 2013 |
Předmět: |
Male
medicine.medical_specialty Bipolar Disorder Adolescent Bipolar disorder lcsh:RC435-571 Val66met polymorphism Criança Neuropsychological Tests Adolescents Young Mania Rating Scale Statistics Nonparametric Wisconsin Card Sorting Test Rating scale lcsh:Psychiatry medicine Humans Child Psychiatry Children Adolescente Depression (differential diagnoses) Intelligence Tests Analysis of Variance Polymorphism Genetic Brain-Derived Neurotrophic Factor Age Factors Transtorno bipolar Cognitive flexibility Fator neurotrófico derivado do encéfalo Executive functions medicine.disease Psychiatry and Mental health BDNF Wisconsin card sorting test Child Preschool Female Psychology |
Zdroj: | Brazilian Journal of Psychiatry, Vol 35, Iss 1, Pp 44-50 (2013) Repositório Institucional da UFRGS Universidade Federal do Rio Grande do Sul (UFRGS) instacron:UFRGS Revista Brasileira de Psiquiatria, Volume: 35, Issue: 1, Pages: 44-50, Published: MAR 2013 Brazilian Journal of Psychiatry v.35 n.1 2013 Brazilian Journal of Psychiatry (São Paulo. 1999. Online) Associação Brasileira de Psiquiatria (ABP) instacron:ABP |
ISSN: | 1516-4446 |
Popis: | OBJECTIVES: To assess the role of the Val66Met polymorphism at the brain-derived neurotrophic factor (BDNF) gene on the performance of children and adolescents with bipolar disorder [juvenile bipolar disorder (JBD)] on the Wisconsin Card Sorting Test (WCST). METHODS: Children and adolescents were assessed by the K-SADS-PL and a clinical evaluation for BD and comorbid conditions. Manic and depressive symptoms were assessed with the Young Mania Rating Scale and the Children Depression Rating Scale - Reviewed. The Val66Met polymorphism at the BDNF was genotyped from a blood sample. Patients' IQ and executive functions were assessed by a standard cognitive flexibility test (WCST). RESULTS: Fifty-three subjects were included in the study. No significant difference was observed between the Val/Val and Val/Met+Met/Met groups on any WCST scores in the MANCOVA (F48,5 = .76; p = .59; Perseverative Errors, p = .66; Nonperseverative Errors, p = .58; Categories Completed, p = .34; Attempts to Reach First Category, p=.64; and Percentage of Conceptual Level Responses, p = .99). CONCLUSIONS: Our findings from this sample of children and adolescents with BD do not replicate results from studies of adults and suggest the existence of differences in the neurobiology of this disorder across the life cycle. Investigations of larger samples are necessary to confirm these data. |
Databáze: | OpenAIRE |
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