Transcription Factor Networks derived from Breast Cancer Stem Cells control the immune response in the Basal subtype
| Autor: | Rolando A R Villacis, W. A. da Silveira, Tatiane M. G. Oliveira, Renata D. Sicchieri, S. du Manoir, Larissa Raquel Mouro Mandarano, Silvia Regina Rogatto, Patricia Vianna Bonini Palma, Valdair Francisco Muglia, Hmr Antonio, Jurandyr Moreira de Andrade, Charles Theillet, Daniel Guimarães Tiezzi |
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| Přispěvatelé: | Universidade de São Paulo (USP), INSERM U1194, Ctr Cell Therapy & Reg Blood Ctr, Vejle Sygehus, Univ Southern Denmark, Universidade de Brasília (UnB), Universidade Estadual Paulista (Unesp), Univ Montpellier, ICM |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Science Breast Neoplasms Biology Bioinformatics Article Metastasis Transcriptome Mice 03 medical and health sciences 0302 clinical medicine Immune system Breast cancer SDG 3 - Good Health and Well-being medicine Journal Article Animals Humans Transcription factor Multidisciplinary Gene Expression Profiling Cancer medicine.disease Gene Expression Regulation Neoplastic Gene expression profiling Disease Models Animal Phenotype 030104 developmental biology 030220 oncology & carcinogenesis Neoplastic Stem Cells Cancer research METÁSTASE NEOPLÁSICA Heterografts Medicine Female Stem cell Biomarkers Protein Binding Signal Transduction Transcription Factors |
| Zdroj: | da Silveira, W A, Palma, P V B, Sicchieri, R D, Villacis, R A R, Mandarano, L R M, Oliveira, T M G, Antonio, H M R, Andrade, J M, Muglia, V F, Rogatto, S R, Theillet, C, du Manoir, S & Tiezzi, D G 2017, ' Transcription Factor Networks derived from Breast Cancer Stem Cells control the immune response in the Basal subtype ', Scientific Reports, vol. 7, no. 1, 2851 . https://doi.org/10.1038/s41598-017-02761-6 Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP da Silveira, W A, Palma, P V B, Sicchieri, R D, Villacis, R A R, Mandarano, L R M, Oliveira, T M G, Antonio, H M R, de Andrade, J M, Rogatto, S R, Theillet, C, du Manoir, S & Tiezzi, D G 2017, ' Transcription Factor Networks derived from Breast Cancer Stem Cells control the immune response in the Basal subtype ', Nature Scientific Reports, vol. 7, 2851 . https://doi.org/10.1038/s41598-017-02761-6 Web of Science Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017) Scientific Reports |
| DOI: | 10.1038/s41598-017-02761-6 |
| Popis: | Made available in DSpace on 2018-11-26T17:34:43Z (GMT). No. of bitstreams: 0 Previous issue date: 2017-06-06 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) INCa grant MOPRECLI INCa grant Role of cancer stem cells during metastatic progression of breast cancer Comprehensive Cancer Center of Montpellier (SIRIC Montpellier-Cancer) Breast cancer is the most common cancer in women worldwide and metastatic dissemination is the principal factor related to death by this disease. Breast cancer stem cells (bCSC) are thought to be responsible for metastasis and chemoresistance. In this study, based on whole transcriptome analysis from putative bCSC and reverse engineering of transcription control networks, we identified two networks associated with this phenotype. One controlled by SNAI2, TWIST1, BNC2, PRRX1 and TBX5 drives a mesenchymal or CSC-like phenotype. The second network is controlled by the SCML4, ZNF831, SP140 and IKZF3 transcription factors which correspond to immune response modulators. Immune response network expression is correlated with pathological response to chemotherapy, and in the Basal subtype is related to better recurrence-free survival. In patient-derived xenografts, the expression of these networks in patient tumours is predictive of engraftment success. Our findings point out a potential molecular mechanism underlying the balance between immune surveillance and EMT activation in breast cancer. This molecular mechanism may be useful to the development of new target therapies. Univ Sao Paulo, Ribeirao Preto Med Sch, Ribeirao Preto, Brazil INSERM U1194, F-34298 Montpellier 5, France Ctr Cell Therapy & Reg Blood Ctr, Natl Inst Sci & Technol Stem Cell & Cell Therapy, Ribeirao Preto, Brazil Vejle Sygehus, Dept Clin Genet, Vejle, Denmark Univ Southern Denmark, Inst Reg Hlth, Odense, Denmark Univ Brasilia UnB, Inst Biol Sci, Dept Genet & Morphol, Brasilia, DF, Brazil Sao Paulo State Univ, Dept Urol, Fac Med, UNESP, Botucatu, SP, Brazil Univ Montpellier, Inst Rech Cancerol Montpellier, F-34298 Montpellier 5, France ICM, F-34298 Montpellier 5, France Univ Sao Paulo, Ribeirao Preto Med Sch, CISBi Ctr Integrat Syst Biol, Ribeirao Preto, Brazil Sao Paulo State Univ, Dept Urol, Fac Med, UNESP, Botucatu, SP, Brazil FAPESP: 11/19758-5 |
| Databáze: | OpenAIRE |
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