Molecularly imprinted polymer-based bulk optode for the determination of itopride hydrochloride in physiological fluids
| Autor: | Nour T. Abdel-Ghani, Fatehy M. Abdel-Haleem, R. M. El Nashar, Adel Madbouly |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Polymers
Biomedical Engineering Biophysics 02 engineering and technology 01 natural sciences Molecular Imprinting ITOPRIDE HYDROCHLORIDE Benzyl Compounds Electrochemistry Humans Chromatography Ionophores Ion exchange Chemistry 010401 analytical chemistry Molecularly imprinted polymer General Medicine 021001 nanoscience & nanotechnology 0104 chemical sciences Benzamides Cholinesterase Inhibitors Optode 0210 nano-technology Selectivity Biotechnology Nuclear chemistry |
| Zdroj: | Biosensors and Bioelectronics. 85:740-742 |
| ISSN: | 0956-5663 |
| DOI: | 10.1016/j.bios.2016.05.081 |
| Popis: | We report here for the first time on the use of Molecularly Imprinted Polymers as modifiers in bulk optodes, Miptode, for the determination of a pharmaceutical compound, itopride hydrochloride as an example in a concentration range of 1×10(-1)-1×10(-4)molL(-1). In comparison to the optode containing the ion exchanger only (Miptode 3), the optode containing the ion exchanger and the MIP particles (Miptode 2) showed improved selectivity over the most lipophilic species, Na(+) and K(+), by more than two orders of magnitude. For instance, the optical selectivity coefficients using Miptode 2, [Formula: see text] , were as follow: NH4(+)˂-6; Na(+)=-4.0, which were greatly enhanced in comparison with that obtained by Miptode 3. This work opens a new avenue for using miptodes for the determination of all the pharmaceutical preparations without the need for the development of new ionophores. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect