Synthesis of Diaryl Diazaphosphonates via 1,6-Hydrophosphonylation of p-Quinone Methides with N-Heterocyclic Phosphine–Thioureas
| Autor: | Nagaraju Molleti, Jun Yong Kang |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Reaction conditions
010405 organic chemistry Chemistry Organic Chemistry Aromatization 010402 general chemistry 01 natural sciences Biochemistry Medicinal chemistry Phosphonate 0104 chemical sciences Quinone Catalysis chemistry.chemical_compound Organic chemistry Physical and Theoretical Chemistry Phosphine |
| Zdroj: | Organic Letters. 19:958-961 |
| ISSN: | 1523-7052 1523-7060 |
| DOI: | 10.1021/acs.orglett.7b00261 |
| Popis: | A mild, efficient method for the synthesis of diaryl diazaphosphonates via 1,6-hydrophosphonylation/aromatization of p-quinone methides (p-QMs) with N-heterocyclic phosphine-thioureas has been developed. This transformation proceeds without any additive or catalyst under mild reaction conditions and tolerates a wide range of p-QMs. This methodology provides a straightforward access to diaryl phosphonate derivatives in good to excellent yields (up to 99%). |
| Databáze: | OpenAIRE |
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