The rat cerebral vasculature exhibits time-of-day-dependent oscillations in circadian clock genes and vascular function that are attenuated following obstructive sleep apnea
| Autor: | Randy F. Crossland, Robert M. Bryan, David J. Durgan |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Cerebral arteries Circadian clock Vasodilation 030204 cardiovascular system & hematology 03 medical and health sciences Cerebral circulation 0302 clinical medicine Internal medicine Circadian Clocks Medicine Animals Rats Long-Evans Circadian rhythm Sleep Apnea Obstructive business.industry Period Circadian Proteins Original Articles Cerebral Arteries medicine.disease Sleep in non-human animals Circadian Rhythm Obstructive sleep apnea Cerebrovascular Disorders Disease Models Animal Endocrinology Neurology Neurology (clinical) Cardiology and Cardiovascular Medicine business 030217 neurology & neurosurgery |
| Zdroj: | Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 37(8) |
| ISSN: | 1559-7016 |
| Popis: | Circadian clock components oscillate in cells of the cardiovascular system. Disruption of these oscillations has been observed in cardiovascular diseases. We hypothesized that obstructive sleep apnea, which is associated with cerebrovascular diseases, disrupts the cerebrovascular circadian clock and rhythms in vascular function. Apneas were produced in rats during sleep. Following two weeks of sham or obstructive sleep apnea, cerebral arteries were isolated over 24 h for mRNA and functional analysis. mRNA expression of clock genes exhibited 24-h rhythms in cerebral arteries of sham rats (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|