HLA-A, HLA-B and HLA-DRB1 haplotype frequencies in Piauí’s volunteer bone marrow donors enrolled at the Brazilian registry
| Autor: | Anaregina S. Araújo, Ester Miranda Pereira, Adalberto Socorro da Silva, Luiza T. Tsuneto, José Renato Pereira de Moura Barroso, Luiz Claudio Demes da Mata Sousa, H.L.A. Sales Filho, Marina Barguil Macêdo, M.G. Carvalho, Semiramis Jamil Hadad do Monte, J.M. Moita Neto |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Volunteers Linkage disequilibrium Adolescent Immunology Population Human leukocyte antigen Linkage Disequilibrium Young Adult Gene Frequency Bone Marrow Cluster Analysis Humans Immunology and Allergy Medicine Registries education HLA-DRB1 Allele frequency Alleles Genetics education.field_of_study HLA-A Antigens business.industry Haplotype General Medicine Middle Aged Tissue Donors HLA-B HLA-A Haplotypes HLA-B Antigens Female business Brazil HLA-DRB1 Chains Demography |
| Zdroj: | Human Immunology. 74:1598-1602 |
| ISSN: | 0198-8859 |
| DOI: | 10.1016/j.humimm.2013.08.283 |
| Popis: | This study aimed to report the antigen and haplotype frequencies (HFs) of volunteer bone marrow donors (VBMDs) from the state of Piauí who were enrolled in the National Volunteer Bone Marrow Donor Registry (REDOME). The research subjects were 21,943 volunteer bone marrow donors, predominantly young adult women (53.3%). The most frequent allelic group was HLA-A2, followed by -DRB1*13, -DRB1*04, -DRB1*07, -B*15, -B∗35, -B*44, -A*24 and -A*03. Of the 2,704 haplotypes observed, the three most frequent haplotypes were A*29 B*44 DRB1*07 (1.45%), A*01 B*08 DRB1*03 (1.4%) and A*03 B*07 DRB1*15 (0.92%). These three haplotypes were in linkage disequilibrium. PCA showed that 98% of the VBMDs have HLA allele frequencies that are very similar to those from Teresina, the capital city of Piauí. According to the PCA results, these municipalities are distributed with a close proximity to Teresina, which in turn has a close genetic proximity to the Hispanic ethnicity, intermediate proximity to Caucasians and Africans and a distant kinship to Amerindians. The hierarchical proximity of the population of Piauí to the Portuguese and Hispanic populations to shows the strong influence of the latter on the former. |
| Databáze: | OpenAIRE |
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