(2R)-2-Methylchromane-2-carboxylic acids: Discovery of selective PPARα agonists as hypolipidemic agents

Autor:	Soumya P. Sahoo, Samuel D. Wright, David E. Moller, Julia K. Boueres, Karen L. MacNaul, Marc C. Ippolito, Joel P. Berger, Arun K. Agrawal, Daniel J. Miller, Pei-Ran Wang, Hiroo Koyama
Rok vydání:	2005
Předmět:	Male Agonist medicine.drug_class Clinical Biochemistry Carboxylic Acids Drug Evaluation Preclinical Pharmaceutical Science Hamster Peroxisome proliferator-activated receptor Biochemistry Chemical synthesis Rats Sprague-Dawley Structure-Activity Relationship chemistry.chemical_compound Dogs Species Specificity In vivo Cricetinae Drug Discovery medicine Animals Humans PPAR alpha Chromans Molecular Biology Hypolipidemic Agents chemistry.chemical_classification Dose-Response Relationship Drug Molecular Structure Cholesterol Organic Chemistry Macaca mulatta In vitro Rats chemistry Drug Design Molecular Medicine
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 15:3347-3351
ISSN:	0960-894X
Popis:	A SAR study was conducted on chromane-2-carboxylic acid toward selective PPARα agonisim. As a result, highly potent, and selective PPARα agonists were discovered. The optimized compound 43 exhibited robust lowering of total cholesterol levels in hamster and dog animal models.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3db3e18a696be690baf72057ee41674b https://doi.org/10.1016/j.bmcl.2005.05.028 Zobrazit plný text záznamu Full Text from ScienceDirect