Cost-benefit analysis of calcium and vitamin D supplements

Autor: Heike A. Bischoff-Ferrari, Connie M. Weaver, Christopher J. Shanahan
Přispěvatelé: University of Zurich, Weaver, Connie M
Rok vydání: 2019
Předmět:
Adult
Male
0301 basic medicine
Relative risk reduction
11221 Clinic for Geriatric Medicine
Cost-Benefit Analysis
Osteoporosis
chemistry.chemical_element
610 Medicine & health
030209 endocrinology & metabolism
Calcium
Cost savings
03 medical and health sciences
2732 Orthopedics and Sports Medicine
0302 clinical medicine
Meta-Analysis as Topic
Environmental health
medicine
Vitamin D and neurology
Humans
media_common.cataloged_instance
Orthopedics and Sports Medicine
Vitamin D
European union
health care economics and organizations
Aged
Randomized Controlled Trials as Topic
media_common
Cost database
Cost–benefit analysis
business.industry
Middle Aged
medicine.disease
Calcium
Dietary
Bone fracture
chemistry
Dietary Supplements
Female
Original Article
Costs and cost analysis
030101 anatomy & morphology
business
Osteoporotic Fractures
Systematic Reviews as Topic
Zdroj: Archives of Osteoporosis
ISSN: 1862-3514
1862-3522
DOI: 10.1007/s11657-019-0589-y
Popis: Summary If all adults with osteoporosis in the European Union (EU) and United States (US) used calcium and vitamin D supplements, it could prevent more than 500,000 fractures/year in the EU and more than 300,000/year in the US and save approximately €5.7 billion and US $3.3 billion annually. Purpose Evaluate the cost-effectiveness of calcium/vitamin D supplementation for preventing osteoporotic fractures. Methods A cost-benefit analysis tool was used to estimate the net cost savings from reduced fracture-related hospital expenses if adults with osteoporosis in the EU and US used calcium/vitamin D supplements. A 14% relative risk reduction of fracture with calcium/vitamin D supplementation from a recent systematic review and meta-analysis of randomized, controlled trials was used as the basis for the benefit estimate. Other model inputs were informed by epidemiologic, clinical, and cost data (2016–2017) obtained via the medical literature or public databases. Analyses estimated the total number of avoided fractures and associated cost savings with supplement use. Net cost benefit was calculated by subtracting the supplements’ market costs from those savings. Results The > 30 million persons in the EU and nearly 11 million in US with osteoporosis experience about 3.9 million and 2.3 million fractures/year and have annual hospital costs exceeding €50 billion and $28 billion. If all persons with osteoporosis used calcium and vitamin D supplements, there would be an estimated 544,687 fewer fractures/year in the EU and 323,566 fewer in the US, saving over €6.9 billion and $3.9 billion; the net cost benefit would be €5,710,277,330 and $3,312,236,252, respectively. Conclusions Calcium and vitamin D supplements are highly cost-effective, and expanded use could considerably reduce fractures and related costs. Although these analyses included individuals aged ≥ 50 years, the observed effects are likely driven by benefits observed in those aged ≥ 65 years. Electronic supplementary material The online version of this article (10.1007/s11657-019-0589-y) contains supplementary material, which is available to authorized users.
Databáze: OpenAIRE
Externí odkaz: