Poor immune responses to influenza vaccination in infants
| Autor: | Yoshinobu Okuno, Nobuo Nagata, Shoki Yano, Kazushige Nagai, Hitoshi Kamiya, Tetsuo Nakayama, Hiroyuki Tsutsumi, Takuji Kumagai, Toyo Okui |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Adult
Male Aging Influenza vaccine Orthomyxoviridae Antibodies Viral Japan Antigen Antibody Specificity Immunity Humans Medicine Lymphocyte Count Lymphocytes Immunization Schedule Immunity Cellular General Veterinary General Immunology and Microbiology biology business.industry Public Health Environmental and Occupational Health Infant Hemagglutination Inhibition Tests biology.organism_classification Vaccination Kinetics Infectious Diseases Immunization Influenza Vaccines Child Preschool Immunology biology.protein Molecular Medicine Female Viral disease Antibody business |
| Zdroj: | Vaccine. 22:3404-3410 |
| ISSN: | 0264-410X |
| Popis: | Twenty-two and 37 infants and young children received two doses of influenza HA vaccine before the 2001-2002 influenza season and before the 2002-2003 season, respectively. Two or three serial specimens were obtained, before and 1 month after the first vaccination as well as 1 month after the second vaccination. Infants showed a significantly poor HI antibody rise and lymphocyte response compared with young children aged > or =12 months. Time kinetics of the lymphoproliferative responses to influenza antigen among young children varied whereas their activities in infants were typically negative before immunization and increased after vaccination. Infants responded poorly to HA influenza vaccine compared with young children. |
| Databáze: | OpenAIRE |
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