Conversion of Aryl Azides to Aminopyridines

Autor:	Sajan C. Patel, Noah Z. Burns
Rok vydání:	2022
Předmět:	Oxygen Azides Aniline Compounds Colloid and Surface Chemistry Nitrogen Pyridines Aminopyridines Benzene General Chemistry Biochemistry Carbon Catalysis
Zdroj:	Journal of the American Chemical Society. 144:17797-17802
ISSN:	1520-5126 0002-7863
DOI:	10.1021/jacs.2c08464
Popis:	A longstanding challenge in fundamental functional group interconversion has been the direct transformation of benzene into pyridine via nitrogen insertion and carbon deletion. Herein, we report a protocol for the transformation of aryl azides, easily accessible from their corresponding anilines, to 2-aminopyridines using blue light and oxygen. Mechanistic studies corroborate that the arene to pyridine conversion is achieved by nitrogen insertion into the benzene ring followed by oxidative carbon extrusion.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dae16e6f0c7f10ead9e6325c509b3f9 https://doi.org/10.1021/jacs.2c08464 Zobrazit plný text záznamu