Heightened Plasma Levels of Transforming Growth Factor Beta (TGF-β) and Increased Degree of Systemic Biochemical Perturbation Characterizes Hepatic Steatosis in Overweight Pediatric Patients: A Cross-Sectional Study
| Autor: | Hayna Malta-Santos, Camila F. Ramos, Bruno B. Andrade, Valéria M. Borges, Jéssica Rebouças-Silva, Caian L. Vinhaes, Junaura R. Barretto, Ney Boa-Sorte, Monica A. S. Torres-Nascimento |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
Risk 0301 basic medicine medicine.medical_specialty Adolescent pediatric obesity cross-sectional studies lcsh:TX341-641 Overweight Chronic liver disease Severity of Illness Index Gastroenterology Article 03 medical and health sciences 0302 clinical medicine Internal medicine Nonalcoholic fatty liver disease Vitamin D and neurology Humans Medicine Child Glycemic transaminases transforming growth factor beta Nutrition and Dietetics biology business.industry non-alcoholic fatty liver disease Alanine Transaminase gamma-Glutamyltransferase medicine.disease digestive system diseases Fatty Liver Ferritin 030104 developmental biology biology.protein Female 030211 gastroenterology & hepatology systemic biochemical perturbation Steatosis medicine.symptom business lcsh:Nutrition. Foods and food supply Body mass index Biomarkers Food Science |
| Zdroj: | Nutrients Volume 12 Issue 6 Nutrients, Vol 12, Iss 1650, p 1650 (2020) |
| ISSN: | 2072-6643 |
| DOI: | 10.3390/nu12061650 |
| Popis: | Nonalcoholic Fatty Liver Disease (NAFLD) is a common cause of chronic liver disease in childhood and strongly associated with obesity. Routine biochemical non-invasive tests remain with low accuracy for diagnosis of NAFLD. We performed a cross-sectional study to examine potential associations between anthropometric and biochemical parameters, specially TGF-&beta a prognosis marker for hepatic steatosis (HS). Between May and October 2019, seventy-two overweight adolescents were enrolled, of which 36 had hepatic steatosis. Hepatic, lipidic and glycemic profiles, and levels of vitamin D, ferritin and TGF-&beta were analyzed. Hierarchical cluster and a discriminant model using canonical correlations were employed to depict the overall expression profile of biochemical markers and the biochemical degree of perturbation. Median values of alanine aminotransferase (ALT), gamma glutamyl transpeptidase (GGT), and TGF-&beta were higher in the adolescents with HS. Values of body mass index (BMI)/age and ALT, but not of TGF-&beta were gradually increased proportionally to augmentation of steatosis severity. In a multivariate analysis, TGF-&beta plasma concentrations were associated with occurrence of hepatic steatosis independent of other covariates. Discriminant analysis confirmed that TGF-&beta concentrations can identify HS cases. Our data reveal that HS patients exhibit a distinct biosignature of biochemical parameters and imply TGF-&beta as an important biomarker to evaluate risk of steatosis development. |
| Databáze: | OpenAIRE |
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