Roles of the Lactogens and Somatogens in Perinatal and Postnatal Metabolism and Growth: Studies of a Novel Mouse Model Combining Lactogen Resistance and Growth Hormone Deficiency
| Autor: | Jennifer Kerr, Samira Alliouachene, Jon Oden, Donald E. Fleenor, Michael Freemark, Sabrina Wentz, Mario Pende, Paul A. Kelly, Subburaman Mohan |
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| Rok vydání: | 2005 |
| Předmět: |
Blood Glucose
Male Aging medicine.medical_specialty Receptors Prolactin medicine.medical_treatment Drug Resistance Biology Hypoglycemia Weight Gain Growth hormone deficiency Mice Endocrinology Insulin resistance Bone Density Somatomedins Internal medicine medicine Animals Insulin Glucose homeostasis Femur Placental lactogen Mice Knockout Osmolar Concentration Placental Lactogen medicine.disease Prolactin Mice Inbred C57BL Glucose Adipose Tissue Animals Newborn Growth Hormone Female Metabolic syndrome Hormone |
| Zdroj: | Endocrinology. 146:103-112 |
| ISSN: | 1945-7170 0013-7227 |
| DOI: | 10.1210/en.2004-0744 |
| Popis: | To delineate the roles of the lactogens and GH in the control of perinatal and postnatal growth, fat deposition, insulin production, and insulin action, we generated a novel mouse model that combines resistance to all lactogenic hormones with a severe deficiency of pituitary GH. The model was created by breeding PRL receptor (PRLR)-deficient (knockout) males with GH-deficient (little) females. In contrast to mice with isolated GH or PRLR deficiencies, double-mutant (lactogen-resistant and GH-deficient) mice on d 7 of life had growth failure and hypoglycemia. These findings suggest that lactogens and GH act in concert to facilitate weight gain and glucose homeostasis during the perinatal period. Plasma insulin and IGF-I and IGF-II concentrations were decreased in both GH-deficient and double-mutant neonates but were normal in PRLR-deficient mice. Body weights of the double mutants were reduced markedly during the first 3–4 months of age, and adults had striking reductions in femur length, plasma IGF-I and IGF binding protein-3 concentrations, and femoral bone mineral density. By age 6–12 months, however, the double-mutant mice developed obesity, hyperleptinemia, fasting hyperglycemia, relative hypoinsulinemia, insulin resistance, and glucose intolerance; males were affected to a greater degree than females. The combination of perinatal growth failure and late-onset obesity and insulin resistance suggests that the lactogen-resistant/GH-deficient mouse may serve as a model for the development of the metabolic syndrome. |
| Databáze: | OpenAIRE |
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