Laminar-Specific Maturation of GABAergic Transmission and Susceptibility to Visual Deprivation Are Related to Endocannabinoid Sensitivity in Mouse Visual Cortex
| Autor: | Kazuhiro Sohya, Yuchio Yanagawa, Bin Jiang, Abdolrahman Sarihi, Tadaharu Tsumoto |
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| Rok vydání: | 2010 |
| Předmět: |
Male
Agonist Aging genetic structures medicine.drug_class medicine.medical_treatment Stimulation In Vitro Techniques Neurotransmission Biology Inhibitory postsynaptic potential Synaptic Transmission Mice Cannabinoid Receptor Modulators medicine Animals Receptors Cannabinoid gamma-Aminobutyric Acid Visual Cortex Mice Knockout Pyramidal Cells General Neuroscience Excitatory Postsynaptic Potentials Articles Endocannabinoid system Electric Stimulation Mice Inbred C57BL Visual cortex medicine.anatomical_structure Evoked Potentials Visual GABAergic Female Cannabinoid Sensory Deprivation Neuroscience Photic Stimulation Endocannabinoids |
| Zdroj: | The Journal of Neuroscience. 30:14261-14272 |
| ISSN: | 1529-2401 0270-6474 |
| Popis: | The developmental period when neuronal responses are modified by visual experience is reported to start and end earlier in layer 4 than in layer 2/3 of the visual cortex, and the maturation of GABAergic inhibitory circuits is suggested to determine the timing of this period. Here, we examine whether the laminar difference in such timing corresponds to a difference in the time course of the functional maturation of GABAergic synaptic transmission to star pyramidal and pyramidal cells in layers 4 and 2/3, respectively, of the mouse visual cortex and whether the development of the strength of GABAergic transmission is affected by visual deprivation in a laminar-specific manner. Our analysis of developmental changes in inhibitory postsynaptic currents of star pyramidal and pyramidal cells evoked by electrical stimulation of afferents or action potentials of fast-spiking GABAergic neurons revealed that there was a sequential maturation of GABAergic function from layers 4 to 2/3. The maturation of inhibition in layer 4 occurred at postnatal week 3, which preceded by 1 week that of layer 2/3. Visual deprivation by dark rearing arrested the functional development of GABAergic transmission in layer 2/3, whereas dark rearing was not so effective in layer 4. GABAergic synapses in layer 2/3 were sensitive to an agonist for cannabinoid type 1 receptors and not normally matured in receptor knock-out mice, whereas those in layer 4 were not so. These results suggest laminar-specific maturation of inhibition and susceptibility to visual deprivation, which may be related to the laminar difference in sensitivity to endocannabinoids. |
| Databáze: | OpenAIRE |
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