Genome-wide location analysis reveals a role for Sub1 in RNA polymerase III transcription

Autor:	Giorgio Dieci, Joël Acker, Audrey Suleau, Géraldine Dubreuil, Magali Michaut, Jean-Christophe Aude, Christine Conesa, Roberto Ferrari, Olivier Lefebvre, Cécile Ducrot, Arounie Tavenet
Jazyk:	angličtina
Rok vydání:	2009
Předmět:	Transcription factories Chromatin Immunoprecipitation Saccharomyces cerevisiae Proteins Transcription Genetic RNA polymerase II Saccharomyces cerevisiae Blotting Far-Western RNA polymerase III Transcription Factors TFIII Gene Expression Regulation Fungal DNA Fungal RNA polymerase II holoenzyme Oligonucleotide Array Sequence Analysis Genetics Multidisciplinary biology General transcription factor Chromosome Mapping Gene Expression Regulation Developmental RNA Polymerase III Biological Sciences DNA-Binding Proteins Mutation biology.protein Transcription factor II F Transcription factor II D Chromosomes Fungal Genome Fungal Transcription factor II B Protein Binding Transcription Factors
Popis:	Human PC4 and the yeast ortholog Sub1 have multiple functions in RNA polymerase II transcription. Genome-wide mapping revealed that Sub1 is present on Pol III-transcribed genes. Sub1 was found to interact with components of the Pol III transcription system and to stimulate the initiation and reinitiation steps in a system reconstituted with all recombinant factors. Sub1 was required for optimal Pol III gene transcription in exponentially growing cells.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3da8c39aeabbeae2a51c8d211336e878 https://europepmc.org/articles/PMC2725013/ Zobrazit plný text záznamu