Stem cell membrane-coated isotretinoin for acne treatment
| Autor: | Tianqi Meng, Jeung-Hoon Lee, Yongri Jin, Shiyi Wang, Mingji Zhu, Ri-Hua Jiang, Fuqiang Zhang, Jing Li, Jinlan Jiang |
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| Rok vydání: | 2020 |
| Předmět: |
lcsh:Medical technology
lcsh:Biotechnology Biomedical Engineering Pharmaceutical Science Medicine (miscellaneous) Bioengineering 02 engineering and technology Absorption (skin) Pharmacology Endocytosis Applied Microbiology and Biotechnology 03 medical and health sciences lcsh:TP248.13-248.65 Keratin medicine Stratum corneum Isotretinoin Acne 030304 developmental biology Transdermal chemistry.chemical_classification 0303 health sciences Stem cell Tight junction integumentary system Chemistry Research 021001 nanoscience & nanotechnology medicine.disease medicine.anatomical_structure lcsh:R855-855.5 Molecular Medicine Nanoparticles 0210 nano-technology medicine.drug |
| Zdroj: | Journal of Nanobiotechnology, Vol 18, Iss 1, Pp 1-12 (2020) Journal of Nanobiotechnology |
| DOI: | 10.21203/rs.3.rs-18278/v1 |
| Popis: | Background Topical isotretinoin is commonly used to treat acne. However, topical isotretinoin has side effects and can hardly permeate through the stratum corneum, the most important skin barrier. Therefore, this study aimed to demonstrate the efficacy of nanoparticles as stable carriers with great curative effects, low side effects, and strong transdermal ability. Results In a rabbit model of hyperkeratinization, STCM-ATRA-NPs showed significant therapeutic efficacy. By contrast, negative therapeutic efficacy was observed in a golden hamster model of hyper sebum production. Scanning electron microscopy and Fourier transform infrared spectral analyses showed that nanoparticles could penetrate the stratum corneum. Western blotting demonstrated that the nanoparticles could enhance the transdermal efficacy of isotretinoin by reducing the effect of keratin and tight junction proteins. Further, nanoparticles enhanced endocytosis, thereby promoting drug penetration and absorption into the skin. Conclusion STCM-ATRA-NPs were demonstrated to control isotretinoin release, reducing its side effects, and efficiently permeating through the skin by reducing the effect of keratin and tight junction proteins and enhancing endocytosis. |
| Databáze: | OpenAIRE |
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