Esculin prevents Lipopolysaccharide/D-Galactosamine-induced acute liver injury in mice
| Autor: | Feng-Hua Pei, Jiutao Qiao, Jing Chen, Weiran Fu, Ya-Ju Du, Yongbin Shen, Ai-Yun Liu |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Lipopolysaccharides Liver tumor Necrosis Lipopolysaccharide medicine.medical_treatment Intraperitoneal injection Anti-Inflammatory Agents Galactosamine Pharmacology Protective Agents Microbiology Antioxidants 03 medical and health sciences Liver disease chemistry.chemical_compound Mice 0302 clinical medicine medicine Animals Aspartate Aminotransferases Liver injury biology Chemistry Alanine Transaminase equipment and supplies medicine.disease Malondialdehyde Esculin Disease Models Animal 030104 developmental biology Infectious Diseases Liver Myeloperoxidase biology.protein Cytokines 030211 gastroenterology & hepatology medicine.symptom Chemical and Drug Induced Liver Injury |
| Zdroj: | Microbial pathogenesis. 125 |
| ISSN: | 1096-1208 |
| Popis: | Liver injury is an important cause of serious liver disease and is characterized by inflammatory and oxidative responses. Esculin, a coumarinic derivative found in Aesculus hippocastanum L., has been shown to exhibit anti-inflammatory and anti-oxidative effects. Here, we investigated the effects and molecular mechanism of esculin on Lipopolysaccharide/D-Galactosamine (LPS/D-Gal)-induced acute liver injury. A mouse model for acute liver injury was induced by intraperitoneal injection with D-Gal and LPS, and was assessed by histology, and serum transaminase analyses. The results showed that esculin significantly reduced the pathological symptoms of acute liver injury, as well as serum AST and ALT levels. LPS/D-Gal-induced liver myeloperoxidase (MPO) activity and malondialdehyde (MDA) content were also suppressed by esculin. Furthermore, LPS/D-Gal-induced liver tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) production were attenuated by esculin. Our data demonstrate that esculin can inhibit nuclear factor kappa B (NF-κB) activation as well as increase nuclear factor E2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) expression. In conclusion, this paper demonstrates that esculin protects liver injury induced by LPS/D-Gal via inhibiting inflammatory and oxidative responses. |
| Databáze: | OpenAIRE |
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