Successful osteoconduction but limited cartilage tissue quality following osteochondral repair by a cell-free multilayered nano-composite scaffold at the knee
| Autor: | Reinhard Windhager, Markus M. Schreiner, Sebastian Apprich, Siegfried Trattnig, Harald Boszotta, Martin Kaipel, Martin Brix, Stephan Domayer, Richard Kellner |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Cartilage Articular Male medicine.medical_specialty Bone Regeneration Adolescent Knee Joint Nanocomposites Cohort Studies Young Adult 03 medical and health sciences 0302 clinical medicine medicine Humans Orthopedics and Sports Medicine Femur Prospective Studies 030212 general & internal medicine Bone regeneration Surgical repair Wound Healing 030222 orthopedics Tissue Scaffolds Ossification business.industry Cartilage Middle Aged Magnetic Resonance Imaging Surgery Treatment Outcome medicine.anatomical_structure Orthopedic surgery Female Implant medicine.symptom business Cartilage Diseases Follow-Up Studies |
| Zdroj: | International Orthopaedics. 40:625-632 |
| ISSN: | 1432-5195 0341-2695 |
| Popis: | The treatment of larger osteochondral lesions in the knee is still a clinical challenge. One promising strategy to overcome this problem could be surgical repair by using a cell-free multilayered nano-composite scaffold. In this prospective cohort study eight consecutive patients which suffered from a single osteochondral lesion (≥1.5 cm2) on the femoral condyle were enrolled. The repair potential of the implant was assessed by using MRI based biochemical MR sequences (T2 mapping) as well as semi-quantitative morphological analyses (MOCART score) at 18 months after the surgery. The clinical outcome was determined at six, 12, 18, and 24 month follow ups by using IKDC, Tegner-Lysholm, and Cincinnati knee scores. Seven out of eight patients showed a complete integration of the scaffold into the border zone and five out of eight patients excellent or good subchondral ossification of the implant at 18 months following implantation. The surface of the repair tissue was found to be intact in all eight patients. T2 mapping data and the zonal T2 index significantly differed in the repair tissue compared to the healthy control cartilage (P |
| Databáze: | OpenAIRE |
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