Effectiveness and tolerability of tapentadol PR in the management of vertebral fracture pain due to bone fragility

Autor:	Elsa Mazzarella, Antonio Del Puente, Alfonso Oriente
Přispěvatelé:	Oriente, A., Mazzarella, E., Del Puente, A.
Rok vydání:	2021
Předmět:	business.industry Osteoporosi Pain Bone fragility Tapentadol Tolerability Anesthesia Medicine Fracture pain Orthopedics and Sports Medicine Surgery business medicine.drug
Zdroj:	Minerva Ortopedica e Traumatologica. 71
ISSN:	1827-1707 0394-3410
DOI:	10.23736/s0394-3410.20.04023-0
Popis:	Background: Fragility fractures are frequent complications of osteoporosis and are associated with acute pain that very often evolves into chronic pain. MetHOdS: this prospective, open-label, single-center, observational study evaluated effectiveness and tolerability of tapentadol prolonged release and assessed the association of tapentadol treatment with sleep quality, physical well-being, patient satisfaction and quality of life in patients with pain after vertebral fracture due to bone fragility. RESULTS: Among 35 patients, a total of 29 (83%) achieved a ≥30% reduction of pain intensity and 13 (37%) patients showed a reduction of the pain on movement and at rest ≥50% after 180 days of treatment. A total of 24 adverse events occurred in 16 patients (46%), 15 of them were mild and nine were moderate, the most frequent events were headache and sleepiness. Sleep quality, physical well-being, Brief pain inventory Questionnaire scores and SF12 Questionnaire scores significantly improved (P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3da3cfad8680358befdae711b3380e07 https://doi.org/10.23736/s0394-3410.20.04023-0 Zobrazit plný text záznamu