Neurotrophin receptor proteins immunoreactivity in the rat cerebellar cortex as a function of age
| Autor: | F. Javier Naves, JoséA. Vega, Miguel Del Valle, I. Esteban, JoséM. Torres |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Male
medicine.medical_specialty Cerebellum Aging animal structures Central nervous system Immunocytochemistry Tropomyosin receptor kinase B Biology Tropomyosin receptor kinase A Antibodies Internal medicine medicine Animals Rats Wistar Receptor Cerebral Cortex Age Factors Proteins Protein-Tyrosine Kinases Immunohistochemistry Rats medicine.anatomical_structure Endocrinology nervous system Cerebellar cortex biology.protein Developmental Biology Neurotrophin |
| Zdroj: | Mechanisms of ageing and development. 83(1) |
| ISSN: | 0047-6374 |
| Popis: | The influence of age on immunohischemically demonstrable neurotrophin receptor proteins (p75, trkA-, trkB-, and trkC-proteins) was studied in the cerebellar cortex of Wistar male rats aged 3 (young), 12 (adult) and 24 (old) months. The number of Purkinje neurons displaying p75, trkA- and trkC-like proteins immunoreactivity (IR), as well as the intensity of p75 and trkA-like protein IR, were significantly reduced in aged rats in comparison with 3 and 12-month-old rats. The intensity of trkC-like protein in the cytoplasm of Purkinje neurons remained unchanged for all the period studied. Moreover, no significant age-dependent changes were observed in the density of p75 or trkC-like proteins IR in the granule neurons layer. The molecular layer showed faint p75 IR which decreased as a function of age. No immunolabelling for neuronal trkB-like proteins was observed, but trkB- and trkC-like proteins IR was found in non-neuronal cells. These results suggest that cerebellar cortex neurons are responsive to and/or dependent upon different neurotrophins. Moreover, the age-dependent impairment in the expression of some neurotrophin receptors in Purkinje neurons, but not in the granule neurons, lends support to a role for neurotrophins in cerebellar aging. |
| Databáze: | OpenAIRE |
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