Intravenous administration of human IgG to newborn infants: changes in serum antibody levels to group B streptococci
| Autor: | Reinhard Seger, Gabriel Duc, D. Mieth, C. H. Kind, Hans Ulrich Bucher, B. Müller, Karen Kvist Christensen, Poul Christensen |
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| Rok vydání: | 1984 |
| Předmět: |
medicine.medical_specialty
Neonatal intensive care unit medicine.medical_treatment Gastroenterology Group B Immunoglobulin G Streptococcus agalactiae Sepsis Antigen Antibody Specificity Internal medicine Streptococcal Infections medicine Humans Infusions Parenteral biology business.industry Infant Newborn Radioimmunoassay medicine.disease Antibodies Bacterial Intravenous therapy Pediatrics Perinatology and Child Health Immunology biology.protein Antibody business |
| Zdroj: | European journal of pediatrics. 143(2) |
| ISSN: | 0340-6199 |
| Popis: | A human IgG preparation was given intravenously to 36 newborn infants admitted to the neonatal intensive care unit because of suspected septicaemia. IgG was given as a single dose of 0.4 g/kg body weight. Patient serum was obtained immediately before and 30 min after terminating the infusion. Blood was also withdrawn 2 days after giving the IgG in eight of the infants. The sera were tested by radioimmunoassay for IgG antibody levels to surface antigens of group B streptococci (GBS) types Ia, Ib, II and III and to R-protein. The mean increases in anti-type Ia, Ib, II, III and R-protein antibodies 30 min after the end of infusion were 81%, 73%, 49%, 60% and 69% of the preinfusion levels, respectively. This was followed by a rapid decrease during the following 2 days to 25%-32% of the initial increases. Based on the above findings, a controlled trial of passive immunisation in the management of neonatal GBS septicaemia seems justified. The rapid decline in antibody levels would necessitate a second infusion 24 h after the initial immunoglobulin administration if the suspicion of septicaemia persists. |
| Databáze: | OpenAIRE |
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