Relationship between morphological and vascular alterations in geographic atrophy using a multimodal imaging approach
Autor: | Magdalena Baratsits, Ursula Schmidt-Erfurth, Reinhard Told, Andreas Pollreisz, Alexander Hecht, Stefan Sacu, Michael Pircher, Christoph K. Hitzenberger, Ramzi Sayegh, Bernhard Baumann |
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Rok vydání: | 2020 |
Předmět: |
Male
medicine.medical_specialty genetic structures Retinal Pigment Epithelium Multimodal Imaging Lesion 03 medical and health sciences 0302 clinical medicine Optical coherence tomography Geographic Atrophy Ophthalmology medicine Humans Prospective Studies Fluorescein Angiography Aged Aged 80 and over Multimodal imaging Retina Retinal pigment epithelium medicine.diagnostic_test Choroid business.industry General Medicine Macular degeneration medicine.disease eye diseases Geographic atrophy Autofluorescence Cross-Sectional Studies medicine.anatomical_structure 030221 ophthalmology & optometry Female sense organs medicine.symptom business Tomography Optical Coherence 030217 neurology & neurosurgery |
Zdroj: | Acta Ophthalmologica. 98 |
ISSN: | 1755-3768 1755-375X |
Popis: | Purpose To assess geographic atrophy (GA) using a multimodal imaging approach, focusing on alterations at the level of the retinal pigment epithelium (RPE) and the choriocapillaris (CC) layers, by lesion demarcation, and assessment of morphological alterations within the atrophic area and in the transition zone. Methods Fifty-seven eyes of 34 patients with atrophic age-related macular degeneration (AMD) were included in this prospective, observational, cross-sectional study. Multimodal imaging using wide-field polarization-sensitive optical coherence tomography (PS-OCT), optical coherence tomography angiography (OCT-A) and fundus autofluorescence (FAF) was performed. The images were overlaid and used to analyse and compare alterations in the retina and the CC. Results Mean atrophic lesion size was 8.15 mm2 (range: 2.23-17.23 mm2 ). In 52 of 57 eyes (91%), OCT-A displayed focal hypodense areas at the CC level in the transition zone of GA, as well as increased focal depolarizing material (e.g. melanin-containing structures) showed in PS-OCT en face depolarizing material maps. These regions of increased depolarizing material at the transition zone corresponded to the hypodense areas on OCT-A scans. All 57 eyes presented with abnormal FAF patterns at the transition zone. All 57 eyes showed distinct alterations of CC flow pattern architecture. Six eyes (11%) demonstrated reduced and three eyes (5%) a complete loss of CC flow pattern architecture across the entire area of GA, while 48 of 57 eyes (84%) presented with irregular mixed patterns of different focal alterations of CC flow architecture within the area of GA. Reduced CC patterns exceeding GA lesion margins into the transitional zone were found in all eyes. Conclusions Optical coherence tomography angiography images revealed different degrees of flow impairment within the atrophic lesion area and its transition zone. Alterations in RPE morphology and tissue integrity resulting in accumulation of depolarizing material, such as melanin, could result in misinterpretation of OCT-A imaging in areas in the shadow of depolarizing material. These changes seem to be partially independent from autofluorescence altering processes. |
Databáze: | OpenAIRE |
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