Proton magnetic resonance spectroscopy of basal ganglia in chronic fatigue syndrome
Autor: | John W. Gow, Barrie Condon, David Brennan, Donald M. Hadley, Abhijit Chaudhuri |
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Rok vydání: | 2003 |
Předmět: |
Adult
Male musculoskeletal diseases medicine.medical_specialty Pathology Magnetic Resonance Spectroscopy Biology Asymptomatic Basal Ganglia Choline Left basal ganglia chemistry.chemical_compound Internal medicine Basal ganglia medicine Chronic fatigue syndrome Humans Patient group Fatigue Syndrome Chronic General Neuroscience virus diseases Middle Aged Creatine medicine.disease Proton magnetic resonance Endocrinology chemistry Gliosis Female Protons medicine.symptom human activities |
Zdroj: | NeuroReport. 14:225-228 |
ISSN: | 0959-4965 |
DOI: | 10.1097/00001756-200302100-00013 |
Popis: | Fatigue is a common symptom of neurological diseases that affect basal ganglia function. We used proton magnetic resonance spectroscopy ((1)H MRS) to study the metabolic functions of the basal ganglia in chronic fatigue syndrome (CFS) to test the hypothesis that fatigue in CFS may have a neurogenic component. (1)H MRS of left basal ganglia was carried out in eight non-psychiatric patients with CFS and their results were compared to age- and sex-matched healthy asymptomatic healthy controls. A highly significant increase in the spectra from choline-containing compounds was seen in the CFS patient group (p < 0.001). In the absence of regional structural or inflammatory pathology, increased choline resonance in CFS may be an indicator of higher cell membrane turnover due to gliosis or altered intramembrane signalling. |
Databáze: | OpenAIRE |
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