Genomic Analysis of Three Metastatic Prostate Cancer Patients with Exceptional Responses to Carboplatin Indicating Different Types of DNA Repair Deficiency

Autor:	Ruth Riisnaes, Arul M. Chinnaiyan, Pasquale Rescigno, Bora Gurel, Susana Miranda, Kevin Kelly, Daniel Nava Rodrigues, Nina Tunariu, Adam Sharp, Diletta Bianchini, Maialen Barrero, Zafeiris Zafeiriou, Colin C. Pritchard, Alec Paschalis, Wei Yuan, Robert Chandler, Joaquin Mateo, Johann S. de Bono, Antonella Petremolo, Semini Sumanasuriya, Suzanne Carreira
Rok vydání:	2018
Předmět:	Adult Male DNA repair Urology 030232 urology & nephrology Antineoplastic Agents Adenocarcinoma Article Carboplatin 03 medical and health sciences Prostate cancer chemistry.chemical_compound 0302 clinical medicine Prostate medicine Humans Precision Medicine Polymerase Platinum Aged DNA repair genes biology business.industry Prostatic Neoplasms Recombinational DNA Repair Genomics Middle Aged medicine.disease DNA Repair-Deficiency Disorders Pedigree Prostatic Neoplasms Castration-Resistant medicine.anatomical_structure chemistry 030220 oncology & carcinogenesis Homologous recombination defects biology.protein Cancer research Cancer biomarkers Homologous recombination business DNA
Zdroj:	European Urology
ISSN:	1873-7560
Popis:	Platinum-based regimens have not been proved to increase survival from advanced prostate cancer (PCa). Incontrovertible evidence that a proportion of prostate cancers have homologous recombination DNA (HRD) repair defects, and that such genomic aberrations are synthetically lethal with both poly(ADP)-ribose polymerase inhibition and platinum, has increased interest in the utilisation of these drugs against a subset of these diseases. Here in we report three patients with advanced castration-resistant PCa with HRD defects having exceptional responses to carboplatin.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d9abcefe4b2be55e1c1cd01909f9ea3 https://pubmed.ncbi.nlm.nih.gov/30482672 Zobrazit plný text záznamu Full Text from ScienceDirect