Oral delivery of diabetes peptides — Comparing standard formulations incorporating functional excipients and nanotechnologies in the translational context
| Autor: | Torsten Haack, Laurent Hortala, Ulrich Werner, Priscilla Brun, Harivardhan Reddy Lakkireddy, Didier Bazile, Rachel Vogel, Melissa Besenius, Brigitte Illel, Matthias Urmann, Jean Alié |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Late development Administration Oral Pharmaceutical Science Context (language use) 02 engineering and technology Bioinformatics Excipients Translational Research Biomedical 03 medical and health sciences Drug Delivery Systems Diabetes mellitus Diabetes Mellitus Animals Humans Medicine business.industry 021001 nanoscience & nanotechnology medicine.disease Nanomedicine 030104 developmental biology Biopharmaceutical Drug delivery Peptides 0210 nano-technology business |
| Zdroj: | Advanced Drug Delivery Reviews. 106:196-222 |
| ISSN: | 0169-409X |
| Popis: | While some orally delivered diabetes peptides are moving to late development with standard formulations incorporating functional excipients, the demonstration of the value of nanotechnology in clinic is still at an early stage. The goal of this review is to compare these two drug delivery approaches from a physico-chemical and a biopharmaceutical standpoint in an attempt to define how nanotechnology-based products can be differentiated from standard oral dosage forms for oral bioavailability of diabetes peptides. Points to consider in a translational approach are outlined to seize the opportunities offered by a better understanding of both the intestinal barrier and of nano-carriers designed for oral delivery. |
| Databáze: | OpenAIRE |
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