Intraperitoneal Administration of Short-Chain Fatty Acids Improves Lipid Metabolism of Long-Evans Rats in a Sex-Specific Manner
| Autor: | Tiffany A. Fillier, Shrushti Shah, Sukhinder K. Cheema, Raymond Thomas, Thu Huong Pham |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Blood Glucose Male Gut flora Fatty Acids Nonesterified chemistry.chemical_compound Eating 0302 clinical medicine gut microbial metabolites Gene expression chemistry.chemical_classification Sex Characteristics Nutrition and Dietetics medicine.diagnostic_test biology 3. Good health Cholesterol Liver Female Cholesterol Esters sex-specific effects lcsh:Nutrition. Foods and food supply Injections Intraperitoneal medicine.medical_specialty short-chain fatty acids lcsh:TX341-641 Butyrate Article lipids 03 medical and health sciences Internal medicine Lipidomics medicine Animals Rats Long-Evans Triglycerides Body Weight Lipid metabolism biology.organism_classification Fatty Acids Volatile Lipid Metabolism Rats 030104 developmental biology Endocrinology chemistry Propionate Lipid profile gene regulation 030217 neurology & neurosurgery Food Science |
| Zdroj: | Nutrients Volume 13 Issue 3 Nutrients, Vol 13, Iss 892, p 892 (2021) |
| ISSN: | 2072-6643 |
| Popis: | Short-chain fatty acids (SCFAs) are microbial metabolites, mainly generated by the action of gut microbiota on dietary fibers. Acetate, propionate, and butyrate are the three main SCFAs produced typically in a 60:20:20 molar ratio in the colon. Acetate, propionate, and butyrate, when given individually as supplements, have shown a protective role in obesity and hyperglycemia however, the sex-specific effects of a mixture of SCFAs, when given in 60:20:20 ratio, on the regulation of lipid metabolism and lipid profile are not known. Male and female Long–Evans rats were given a mixture of SCFAs (acetate, propionate, and butyrate molar ratio 60:20:20) each day for seven days intraperitoneally plasma and hepatic lipids, gene expression, and lipidomics profile were analyzed. SCFAs significantly decreased plasma and hepatic triglycerides and cholesterol in males, whereas the fatty acyl composition of cholesteryl esters, triglycerides, and phospholipids was modulated in females. SCFAs decreased the mRNA expression of hepatic acetyl-CoA carboxylase-1 in both males and females. Our findings demonstrate for the first time that SCFAs (60:20:20) improved plasma and hepatic lipid levels and fatty acyl composition in a manner that may provide cardio-protective and anti-inflammatory effects in both sexes, via independent mechanisms. |
| Databáze: | OpenAIRE |
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