Spatial memory deficits and thalamic serotonergic metabolite change in thiamine deficient rats
| Autor: | Ieda F. Oliveira-Silva, Fabio Antônio Borges Vigil, Lívia Freire Ferreira, Silvia R.C. Pereira, Angela Maria Ribeiro |
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| Rok vydání: | 2010 |
| Předmět: |
Male
Serotonin Time Factors Metabolite Morris water navigation task Neuropsychological Tests Serotonergic Behavioral Neuroscience chemistry.chemical_compound Thalamus medicine Animals Memory disorder Rats Wistar Maze Learning Analysis of Variance Memory Disorders Cognitive disorder Thiamine Deficiency Hydroxyindoleacetic Acid medicine.disease Rats B vitamins Pyrithiamine chemistry Space Perception Thiamine Psychology Neuroscience |
| Zdroj: | Behavioural Brain Research. 210:140-142 |
| ISSN: | 0166-4328 |
| DOI: | 10.1016/j.bbr.2010.02.019 |
| Popis: | The purposes of the present study were to verify the effects of a severe thiamine deficiency episode on spatial cognitive aspects and thalamic serotonergic parameters. The animals were submitted to a severe thiamine deficiency treatment that was interrupted after the onset of the last neurological signs. The results obtained confirm previous findings about TD deficiency effects on cognitive function and, further show that this vitamin increases the thalamic serotonine metabolite, 5-hidroxyindolacetic acid (5-HIAA), level. In addition, the present data shed light on the importance of this metabolite in spatial cognitive function. |
| Databáze: | OpenAIRE |
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