Cardamonin suppresses melanogenesis by inhibition of Wnt/beta-catenin signaling
| Autor: | Jong-Sub Han, Sang-Jin Kang, Min-Jung Ryu, Mu-Hyun Jin, Sangtaek Oh, Young-Hwa Chung, Munju Cho, Ho-Jeoung Kim, Min-Youl Chang, Dong-Eun Kim, Cheon-Koo Lee, Ho-Song Cho, Yongsu Jeong |
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| Rok vydání: | 2009 |
| Předmět: |
Beta-catenin
Indoles Tyrosinase Biophysics Skin Pigmentation Protein degradation Melanocyte Biochemistry Cell Line Melanin Glycogen Synthase Kinase 3 Chalcones GSK-3 Oximes medicine Humans Molecular Biology beta Catenin Melanins biology Wnt signaling pathway Cell Biology Microphthalmia-associated transcription factor Wnt Proteins medicine.anatomical_structure biology.protein Cancer research Melanocytes |
| Zdroj: | Biochemical and biophysical research communications. 390(3) |
| ISSN: | 1090-2104 |
| Popis: | Wnt/beta-catenin signaling plays important roles in many developmental processes, including neural crest-derived melanocyte development. Here we show that cardamonin, a calchone from Aplinia katsumadai Hayata, inhibited pigmentation in melanocytes through suppression of Wnt/beta-catenin signaling pathway. Cardamonin significantly suppressed the expression of microphthalmia-associated transcription factor (MITF) and tyrosinase, which are melanocyte differentiation-associated markers, in human normal melanocytes, thereby decreasing intracellular melanin production. In addition, cardamonin promoted the degradation of intracellular beta-catenin that was accumulated by Wnt3a-conditioned medium (Wnt3a CM) or bromoindirubin-3'-oxime (BIO), a glycogen synthase kinase-3beta (GSK-3beta) inhibitor, in HEK293 reporter cells and human normal melanocytes. Our findings indicate that cardamonin may be a potential whitening agent for use in cosmetics and in the medical treatment of hyperpigmentation disorders. |
| Databáze: | OpenAIRE |
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