Expression of IFN-gamma-inducible protein; monocyte chemotactic proteins 1, 3, and 4; and eotaxin in TH1- and TH2-mediated lung diseases
| Autor: | Deborah Miotto, Anne Tsicopoulos, Qutayba Hamid, Pota Christodoulopoulos, Lisa Cameron, Christina E. Mapp, Andy D. Luster, Olivier Fahy, Jean Jacques Lafitte, Ron Olivenstein, Benoit Wallaert, Rame Taha, André-Bernard Tonnel |
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| Rok vydání: | 2001 |
| Předmět: |
Eotaxin
Chemokine CCL11 Lung Diseases Chemokine Chronic bronchitis medicine.medical_treatment Immunology Immune system Th2 Cells medicine Immunology and Allergy Humans Interferon gamma Chemokine CCL7 Chemokine CCL2 Lung biology medicine.diagnostic_test business.industry respiratory system Th1 Cells Immunohistochemistry respiratory tract diseases Monocyte Chemoattractant Proteins Chemokine CXCL10 Bronchoalveolar lavage Cytokine medicine.anatomical_structure Chemokines CC biology.protein Cytokines business Chemokines CXC medicine.drug |
| Zdroj: | The Journal of allergy and clinical immunology. 107(4) |
| ISSN: | 0091-6749 |
| Popis: | Chemokines are involved in the influx of leukocytes into the airways in inflammatory lung diseases. The differential cell recruitment characteristic of T(H)1 versus T(H)2 immune responses may be associated with differential chemokine expression.We investigated the expression of chemokines; monocyte chemotactic proteins (MCPs) 1, 3, and 4; eotaxin; and IFN-gamma-inducible protein 10 (IP-10) in both T(H)1- and T(H)2-mediated lung diseases.By using immunocytochemistry and in situ hybridization, we examined the protein and mRNA expression, respectively, in bronchoalveolar lavage and biopsy samples in subjects with asthma, tuberculosis, sarcoidosis, and chronic bronchitis.Increased immunoreactivity and mRNA expression of IP-10 and of the MCPs was found in the bronchoalveolar lavage fluid and biopsy specimens of subjects with asthma and tuberculosis compared with that of control subjects (P.005). IP-10, however, was particularly increased in subjects with sarcoidosis (P.001). Eotaxin, on the other hand, was increased only in patients with asthma when compared with control subjects (P.005).This study demonstrates that MCP-1, MCP-3, and MCP-4 expression is not specifically associated with lung diseases characterized by a particular cytokine profile. In contrast, IP-10 is mostly expressed in T(H)1-mediated diseases, and eotaxin expression seems to be specifically associated with lung diseases of a T(H)2 cytokine profile. |
| Databáze: | OpenAIRE |
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