Comparison of the effects of e-cigarette vapor with cigarette smoke on lung function and inflammation in mice
| Autor: | Vassiliki Karavana, Athanasia Pavlidou, Christina Magkou, Stavros Topouzis, Paraskevi Katsaounou, Sofia-Iris Bibli, Andreas Papapetropoulos, Ioannis Kalomenidis, Spyros Zakynthinos, Constantinos Glynos |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Pulmonary and Respiratory Medicine Male Physiology medicine.medical_treatment Inflammation Electronic Nicotine Delivery Systems 03 medical and health sciences Mice 0302 clinical medicine Cigarette smoking In vivo Physiology (medical) medicine Respiratory Hypersensitivity Cigarette smoke Animals Lung function Lung business.industry Vaping Smoking Cell Biology respiratory system Mice Inbred C57BL Oxidative Stress 030104 developmental biology medicine.anatomical_structure 030228 respiratory system Nicotine delivery Immunology Smoking cessation medicine.symptom business |
| Zdroj: | American journal of physiology. Lung cellular and molecular physiology. 315(5) |
| ISSN: | 1522-1504 |
| Popis: | Electronic cigarettes (e-cigs) are advertised as a less harmful nicotine delivery system or as a new smoking cessation tool. We aimed to assess the in vivo effects of e-cig vapor in the lung and to compare them to those of cigarette smoke (CS). We exposed C57BL/6 mice for either 3 days or 4 wk to ambient air, CS, or e-cig vapor containing 1) propylene glycol/vegetable glycerol (PG:VG-Sol; 1:1), 2) PG:VG with nicotine (G:VG-N), or 3) PG:VG with nicotine and flavor (PG:VG-N+F) and determined oxidative stress, inflammation, and pulmonary mechanics. E-cig vapors, especially PG:VG-N+F, increased bronchoalveolar lavage fluid (BALF) cellularity, Muc5ac production, as well as BALF and lung oxidative stress markers at least comparably and in many cases more than CS. BALF protein content at both time points studied was only elevated in the PG:VG-N+F group. After 3 days, PG:VG-Sol altered tissue elasticity, static compliance, and airway resistance, whereas after 4 wk CS was the only treatment adversely affecting these parameters. Airway hyperresponsiveness in response to methacholine was increased similarly in the CS and PG:VG-N+F groups. Our findings suggest that exposure to e-cig vapor can trigger inflammatory responses and adversely affect respiratory system mechanics. In many cases, the added flavor in e-cigs exacerbated the detrimental effects of e-cig vapor. We conclude that both e-cig vaping and conventional cigarette smoking negatively impact lung biology. |
| Databáze: | OpenAIRE |
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