Supplementary Figures 1-4 from Concurrent HER or PI3K Inhibition Potentiates the Antitumor Effect of the ERK Inhibitor Ulixertinib in Preclinical Pancreatic Cancer Models

Autor: Kian-Huat Lim, Andrea Wang-Gillam, Qiong Li, Daoxiang Zhang, Maureen Highkin, Paarth Dodhiawala, Patrick Grierson, Lin Li, Mai Xu, Hongmei Jiang
Rok vydání: 2023
DOI: 10.1158/1535-7163.22504564.v1
Popis: Supplementary Figure 1. Ulixertinib potentiates gemcitabine effect and this combination is well tolerated in mice; Supplementary Figure 2. Pharmacologic ERK inhibition increases p-MEK, ERK and AKT; Supplementary Figure 3. Ulixertinib synergizes with HER inhibitors; Supplementary Figure 4. Ulixertinib synergizes with PI3K Inhibitor
Databáze: OpenAIRE