Prospective Follow-Up of Cortical Interruptions, Bone Density, and Micro-structure Detected on HR-pQCT: A Study in Patients with Rheumatoid Arthritis and Healthy Subjects
Autor: | D. Loeffen, J. van den Bergh, Piet Geusens, René Weijers, B. van Rietbergen, A. van Tubergen, A. Scharmga, M. Peters |
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Přispěvatelé: | RS: NUTRIM - R2 - Liver and digestive health, RS: CAPHRI - R3 - Functioning, Participating and Rehabilitation, Promovendi NTM, Interne Geneeskunde, RS: NUTRIM - R3 - Respiratory & Age-related Health, Promovendi PHPC, MUMC+: DA BV Medisch Specialisten Radiologie (9), MUMC+: MA Reumatologie (9), Orthopaedic Biomechanics |
Jazyk: | angličtina |
Rok vydání: | 2019 |
Předmět: |
0301 basic medicine
RADIOGRAPHS Bone Regeneration Bone density Endocrinology Diabetes and Metabolism Radiography Disease modifying anti-rheumatic drugs SDG 3 – Goede gezondheid en welzijn Arthritis Rheumatoid 0302 clinical medicine Endocrinology Bone Density Cortical interruptions Orthopedics and Sports Medicine Longitudinal Studies Prospective Studies Quantitative computed tomography medicine.diagnostic_test Healthy subjects Middle Aged Rheumatoid arthritis Antirheumatic Agents Disease Progression Female Adult musculoskeletal diseases medicine.medical_specialty 030209 endocrinology & metabolism Micro structure Bone and Bones 03 medical and health sciences SDG 3 - Good Health and Well-being Finger Joint medicine Bone mineral density Humans In patient REPAIR EROSIONS business.industry QUANTITATIVE COMPUTED-TOMOGRAPHY High-resolution peripheral quantitative computed tomography medicine.disease METACARPOPHALANGEAL JOINTS Case-Control Studies Orthopedic surgery 030101 anatomy & morphology business Nuclear medicine Tomography X-Ray Computed Follow-Up Studies |
Zdroj: | Calcified Tissue International, 104(6), 571-581. Springer, Cham Calcified Tissue International, 104(6), 571-581. Springer |
ISSN: | 0171-967X |
Popis: | ObjectivesThe purpose of the study was to prospectively investigate change (repair or progression) in the number, surface area and volume of cortical interruptions, bone density (vBMD) and micro-structural parameters assessed by high-resolution peripheral quantitative computed tomography (HR-pQCT) in finger joints of patients with rheumatoid arthritis (RA) treated with synthetic disease modifying anti-rheumatic drugs (sDMARDs) and/or biologic DMARDs (bDMARDs) over a 1-year follow-up period, and in comparison with healthy subjects (HS).MethodsThirty-two patients with RA (221 joints, 53% on bDMARDs) and 32 HS (117 joints) were assessed at baseline and after 1year using semi-automatic analysis of HR-pQCT images. Mean changes (group level) and the proportion of joints (joint level) with changes beyond the least significant change were calculated.ResultsAt baseline, 530 interruptions were identified in patients, and 136 in HS. The mean of the interruption parameters did not significantly change in either group Mean vBMD decreased more in patients than in HS (-4.4 versus -1.1 mgHA/cm(3), respectively). In patients versus HS, proportionally more joints showed repair in interruption volume (6.6% versus 1.7%, respectively) and loss of vBMD (26.7% versus 12.9%, respectively). In patients on sDMARDs versus patients on bDMARDs, proportionally more joints showed progression in the number of interruptions and loss of vBMD (6.1% versus 1.8% and 31.3% versus 17.2%, respectively).ConclusionsHR-pQCT is able to quantify bone repair and progression. Cortical interruption-, vBMD-, and micro-structure were impaired in RA, of which vBMD and micro-structure further deteriorated, particularly in patients on sDMARDs. The study is supported by unrestricted grants from the Weijerhorst foundation (WH-2) and Pfizer (WS2056904). |
Databáze: | OpenAIRE |
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