Prospective Follow-Up of Cortical Interruptions, Bone Density, and Micro-structure Detected on HR-pQCT: A Study in Patients with Rheumatoid Arthritis and Healthy Subjects

Autor: D. Loeffen, J. van den Bergh, Piet Geusens, René Weijers, B. van Rietbergen, A. van Tubergen, A. Scharmga, M. Peters
Přispěvatelé: RS: NUTRIM - R2 - Liver and digestive health, RS: CAPHRI - R3 - Functioning, Participating and Rehabilitation, Promovendi NTM, Interne Geneeskunde, RS: NUTRIM - R3 - Respiratory & Age-related Health, Promovendi PHPC, MUMC+: DA BV Medisch Specialisten Radiologie (9), MUMC+: MA Reumatologie (9), Orthopaedic Biomechanics
Jazyk: angličtina
Rok vydání: 2019
Předmět:
0301 basic medicine
RADIOGRAPHS
Bone Regeneration
Bone density
Endocrinology
Diabetes and Metabolism
Radiography
Disease modifying anti-rheumatic drugs
SDG 3 – Goede gezondheid en welzijn
Arthritis
Rheumatoid
0302 clinical medicine
Endocrinology
Bone Density
Cortical interruptions
Orthopedics and Sports Medicine
Longitudinal Studies
Prospective Studies
Quantitative computed tomography
medicine.diagnostic_test
Healthy subjects
Middle Aged
Rheumatoid arthritis
Antirheumatic Agents
Disease Progression
Female
Adult
musculoskeletal diseases
medicine.medical_specialty
030209 endocrinology & metabolism
Micro structure
Bone and Bones
03 medical and health sciences
SDG 3 - Good Health and Well-being
Finger Joint
medicine
Bone mineral density
Humans
In patient
REPAIR
EROSIONS
business.industry
QUANTITATIVE COMPUTED-TOMOGRAPHY
High-resolution peripheral quantitative computed tomography
medicine.disease
METACARPOPHALANGEAL JOINTS
Case-Control Studies
Orthopedic surgery
030101 anatomy & morphology
business
Nuclear medicine
Tomography
X-Ray Computed
Follow-Up Studies
Zdroj: Calcified Tissue International, 104(6), 571-581. Springer, Cham
Calcified Tissue International, 104(6), 571-581. Springer
ISSN: 0171-967X
Popis: ObjectivesThe purpose of the study was to prospectively investigate change (repair or progression) in the number, surface area and volume of cortical interruptions, bone density (vBMD) and micro-structural parameters assessed by high-resolution peripheral quantitative computed tomography (HR-pQCT) in finger joints of patients with rheumatoid arthritis (RA) treated with synthetic disease modifying anti-rheumatic drugs (sDMARDs) and/or biologic DMARDs (bDMARDs) over a 1-year follow-up period, and in comparison with healthy subjects (HS).MethodsThirty-two patients with RA (221 joints, 53% on bDMARDs) and 32 HS (117 joints) were assessed at baseline and after 1year using semi-automatic analysis of HR-pQCT images. Mean changes (group level) and the proportion of joints (joint level) with changes beyond the least significant change were calculated.ResultsAt baseline, 530 interruptions were identified in patients, and 136 in HS. The mean of the interruption parameters did not significantly change in either group Mean vBMD decreased more in patients than in HS (-4.4 versus -1.1 mgHA/cm(3), respectively). In patients versus HS, proportionally more joints showed repair in interruption volume (6.6% versus 1.7%, respectively) and loss of vBMD (26.7% versus 12.9%, respectively). In patients on sDMARDs versus patients on bDMARDs, proportionally more joints showed progression in the number of interruptions and loss of vBMD (6.1% versus 1.8% and 31.3% versus 17.2%, respectively).ConclusionsHR-pQCT is able to quantify bone repair and progression. Cortical interruption-, vBMD-, and micro-structure were impaired in RA, of which vBMD and micro-structure further deteriorated, particularly in patients on sDMARDs. The study is supported by unrestricted grants from the Weijerhorst foundation (WH-2) and Pfizer (WS2056904).
Databáze: OpenAIRE
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