PP2A Phosphatases Take a Giant Leap in the Post-Genomics Era
| Autor: | Malathi Bheri, Girdhar K. Pandey |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Proteomics
0106 biological sciences Stress signaling Phosphatase Genomics Computational biology Biology 01 natural sciences Article Catalytic C subunit Ser/Thr phosphatases Regulatory B subunit 03 medical and health sciences Protein phosphorylation Protein phosphatases Genetics Genetics (clinical) Transcriptome profiling 030304 developmental biology 0303 health sciences Kinase Protein phosphatase 2 PP2A Scaffolding A subunit Signal transduction Functional genomics 010606 plant biology & botany |
| Zdroj: | Current Genomics |
| ISSN: | 1389-2029 |
| DOI: | 10.2174/1389202920666190517110605 |
| Popis: | Background: Protein phosphorylation is an important reversible post-translational modification, which regulates a number of critical cellular processes. Phosphatases and kinases work in a concerted manner to act as a “molecular switch” that turns-on or - off the regulatory processes driving the growth and development under normal circumstances, as well as responses to multiple stresses in plant system. The era of functional genomics has ushered huge amounts of information to the framework of plant systems. The comprehension of who’s who in the signaling pathways is becoming clearer and the investigations challenging the conventional functions of signaling components are on a rise. Protein phosphatases have emerged as key regulators in the signaling cascades. PP2A phosphatases due to their diverse holoenzyme compositions are difficult to comprehend. Conclusion: In this review, we highlight the functional versatility of PP2A members, deciphered through the advances in the post-genomic era. |
| Databáze: | OpenAIRE |
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