Neurons in the dorsomedial hypothalamus promote, prolong, and deepen torpor in the mouse
| Autor: | Timna Hitrec, Anthony E. Pickering, Matteo Cerri, Michael Ambler, Andrew M. Wilson |
|---|---|
| Přispěvatelé: | Ambler M., Hitrec T., Wilson A., Cerri M., Pickering A. |
| Rok vydání: | 2021 |
| Předmět: |
endocrine system
Torpor Central nervous system Hypothalamus Dorsomedial Hypothalamic Nucleus Biology TRAP Mice dorsomedial Mouse Hypothalamus medicine Animals Circadian rhythm hypothalamus Neurons thermoregulation Animal General Neuroscience Neuron Thermoregulation hypothalamu Preoptic Area Preoptic area medicine.anatomical_structure Dorsomedial Hypothalamic Nucleu Dimenhydrinate Female metabolism Neuroscience torpor Homeostasis Anaesthesia Pain and Critical Care |
| Zdroj: | Ambler, M, Hitrec, T, Wilson, A, Cerri, M & Pickering, A 2022, ' Neurons in the Dorsomedial Hypothalamus Promote, Prolong, and Deepen Torpor in the Mouse ', The Journal of neuroscience : the official journal of the Society for Neuroscience, vol. 42, no. 21, pp. 4267-4277 . https://doi.org/10.1523/JNEUROSCI.2102-21.2022 |
| Popis: | Torpor is a naturally occurring, hypometabolic, hypothermic state engaged by a wide range of animals in response to imbalance between the supply and demand for nutrients. Recent work has identified some of the key neuronal populations involved in daily torpor induction in mice, in particular projections from the preoptic area of the hypothalamus (POA) to the dorsomedial hypothalamus (DMH). The DMH plays a role in thermoregulation, control of energy expenditure, and circadian rhythms, making it well positioned to contribute to the expression of torpor. We used activity dependent genetic TRAPing techniques to target DMH neurons that were active during natural torpor bouts in female mice. Chemogenetic reactivation of torpor-TRAPed DMH neurons in calorie-restricted mice promoted torpor, resulting in longer and deeper torpor bouts. Chemogenetic inhibition of torpor-TRAPed DMH neurons did not block torpor entry, suggesting a modulatory role for the DMH in the control of torpor. This work adds to the evidence that the POA and the DMH form part of a circuit within the mouse hypothalamus that controls entry into daily torpor.SignificanceDaily heterotherms such as mice employ torpor to cope with environments in which the supply of metabolic fuel is not sufficient for the maintenance of normothermia. Daily torpor involves reductions in body temperature, as well as active suppression of heart rate and metabolism. How the central nervous system controls this profound deviation from normal homeostasis is not known, but a projection from the preoptic area to the dorsomedial hypothalamus has recently been implicated. We demonstrate that the dorsomedial hypothalamus contains neurons that are active during torpor. Activity in these neurons promotes torpor entry and maintenance, but their activation alone does not appear to be sufficient for torpor entry. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|