Accelerated Progression of Disseminated Coccidioidomycosis Following SARS-CoV-2 Infection: A Case Report

Autor:	Christina M. Jamros, Niels Olson, Ryan C. Maves, Daniel S. Krauth, Shayna C Rivard
Rok vydání:	2021
Předmět:	0301 basic medicine Senescence viruses Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Case Report Disseminated coccidioidomycosis Disease 03 medical and health sciences 0302 clinical medicine Immune system Humans Medicine Coccidioides skin and connective tissue diseases Subclinical infection Coccidioidomycosis biology SARS-CoV-2 business.industry fungi Public Health Environmental and Occupational Health COVID-19 General Medicine biochemical phenomena metabolism and nutrition medicine.disease biology.organism_classification body regions 030104 developmental biology 030220 oncology & carcinogenesis Immunology AcademicSubjects/MED00010 business CD8
Zdroj:	Military Medicine
ISSN:	1930-613X 0026-4075
DOI:	10.1093/milmed/usab132
Popis:	We describe a patient with subclinical coccidioidomycosis who experienced rapid disease dissemination shortly after SARS-CoV-2 infection, suggesting host immune response dysregulation to coccidioidomycosis by SARS-CoV-2. We hypothesize that disrupted cell-mediated signaling may result after SARS-CoV-2 infection leading to functional exhaustion and CD8+ T-cell senescence with impairment in host cellular response to Coccidioides infection.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d9009724b9dfdaaa2adc550f1d1df14 https://doi.org/10.1093/milmed/usab132 Zobrazit plný text záznamu Plný text ve formátu PDF