Novel Marine Secondary Metabolites Worthy of Development as Anticancer Agents: A Review
| Autor: | Yunkai Zhang, Akachukwu Marytheresa Onwuka, Yangbin Huang, Ikechukwu Emmanuel Peter, Justus Amuche Nweze, Mingguo Jiang, Liyan Yang, Shushi Huang, Dengfeng Yang, Lixia Pan, Florence N. Mbaoji, Cynthia Chioma Mbaoji |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Aquatic Organisms
Cell Survival Secondary Metabolism Pharmaceutical Science Organic chemistry Antineoplastic Agents Review Biology lead optimization Analytical Chemistry QD241-441 Cell Line Tumor Neoplasms Drug Discovery Ic50 values medicine Animals Humans Malignant cells cancer Physical and Theoretical Chemistry Cell Proliferation Biological Products Cancer Biological activity medicine.disease drug development Drug development Chemistry (miscellaneous) Cancer cell Cancer research marine secondary metabolites Molecular Medicine Cancer cell lines cancer cell line |
| Zdroj: | Molecules, Vol 26, Iss 5769, p 5769 (2021) Molecules |
| ISSN: | 1420-3049 |
| Popis: | Secondary metabolites from marine sources have a wide range of biological activity. Marine natural products are promising candidates for lead pharmacological compounds to treat diseases that plague humans, including cancer. Cancer is a life-threatening disorder that has been difficult to overcome. It is a long-term illness that affects both young and old people. In recent years, significant attempts have been made to identify new anticancer drugs, as the existing drugs have been useless due to resistance of the malignant cells. Natural products derived from marine sources have been tested for their anticancer activity using a variety of cancer cell lines derived from humans and other sources, some of which have already been approved for clinical use, while some others are still being tested. These compounds can assault cancer cells via a variety of mechanisms, but certain cancer cells are resistant to them. As a result, the goal of this review was to look into the anticancer potential of marine natural products or their derivatives that were isolated from January 2019 to March 2020, in cancer cell lines, with a focus on the class and type of isolated compounds, source and location of isolation, cancer cell line type, and potency (IC50 values) of the isolated compounds that could be a guide for drug development. |
| Databáze: | OpenAIRE |
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