Combinatorial application of dissolving microneedle patch and cream for improvement of skin wrinkles, dermal density, elasticity, and hydration
| Autor: | Suyong Kim, Geonwoo Kang, Mingyu Jang, Huisuk Yang, Ji Hwoon Baek, Go Woon Choi, Hyungil Jung, Ja Hyun Ryu, Liching Chiang |
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| Rok vydání: | 2018 |
| Předmět: |
Drug
Adenosine media_common.quotation_subject Skin Cream Transdermal Patch Dermatology Cosmetic Techniques Administration Cutaneous 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Drug Delivery Systems Double-Blind Method Medicine Humans Hyaluronic Acid media_common Transdermal Skin business.industry Middle Aged Combined Modality Therapy Elasticity Skin Aging Topical cream Skin irritation Treatment Outcome 030220 oncology & carcinogenesis Face Drug delivery Female business Biomedical engineering |
| Zdroj: | Journal of cosmetic dermatology. 18(4) |
| ISSN: | 1473-2165 |
| Popis: | BACKGROUND Dissolving microneedles (DMNs), microscale needles with a biodegradable polymer matrix, have been widely investigated for transdermal drug delivery. However, the restricted drug loading space of DMNs limited the delivery of the desired quantity of active compounds. In this study, we developed novel combinatorial therapies involving sequential application of adenosine-loaded DMN (Ad-DMN) patches and a topical adenosine-loaded cream (Ad-cream). The application of DMNs created skin channels, which delivered encapsulated drugs from both the DMNs and cream. The use of combinatorial therapies can maximize drug delivery. METHODS To compare the efficacy of combinatorial therapies and Ad-cream application, a double-blind clinical test was conducted over 10 weeks on 21 females with wrinkles around their eyes, and the skin parameters such as wrinkles, dermal density, elasticity, and hydration were analyzed. The skin irritation test was assessed by expert interviewers to elucidate undesirable side effects. RESULTS The combinatorial therapies showed statistically significant efficacy for the improvement of average depth of wrinkles, dermal density, elasticity, and hydration after an 8-week application (P |
| Databáze: | OpenAIRE |
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