Genetic Polymorphisms in SOD (rs2070424, rs7880) and CAT (rs7943316, rs1001179) Enzymes Are Associated with Increased Body Fat Percentage and Visceral Fat in an Obese Population from Central Mexico
| Autor: | Inés Romo-Palafox, Ana Bertha Pérez-Lizaur, Paulina Hernandez-Chavez, Grecia Blanco-Melo, Alicia Parra-Carriedo, César Hernández-Guerrero |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
0301 basic medicine Heterozygote medicine.medical_specialty Genotype Population Blood Pressure Single-nucleotide polymorphism Intra-Abdominal Fat Biology Polymorphism Single Nucleotide Increased body fat percentage 03 medical and health sciences Superoxide Dismutase-1 Diabetes mellitus Internal medicine Diabetes Mellitus medicine Humans Obesity education Mexico education.field_of_study Anthropometry Superoxide Dismutase General Medicine Middle Aged Catalase medicine.disease 030104 developmental biology Blood pressure Endocrinology Adipose Tissue Female Dyslipidemia |
| Zdroj: | Archives of Medical Research. 47:331-339 |
| ISSN: | 0188-4409 |
| Popis: | Oxidative disturbance is an important factor involved in the etiology of comorbidities associated with obesity. Genetic polymorphisms such as SOD1 -251AG, SOD2 47 CT, CAT -21AT and CAT -262 CT have been described to alter the activity of antioxidant enzymes. The aim of the present work was to analyze the association of the mentioned SNPs with obesity and their relationship with anthropometric and clinical variables in this group.The study included 416 Mexican women (208 normal weight, NW and 208 subjects with obesity, OB). Dietary intake, anthropometric, biochemical and clinical features were evaluated and then analyzed in function of the genotypes.The mutated carriers (GA+GG) of SOD -251 were significantly higher in the OB group (0.24) compared to the NW group (0.08). The other SNPs showed no differences compared with control group. When comparing carrier mutated subjects with obesity vs. wild-type obese participants with the SNPs SOD1 -251, SOD2 47 and CAT -262, the carriers showed a significantly (p0.05) higher value in body fat percentage. Also, carriers of SOD2 47 and CAT-262 showed significantly higher values (p = 0.002) and (p = 0.01), respectively, when visceral fat was compared between groups. Systolic blood pressure was significantly higher (p = 0.02) in carriers of mutated CAT-21.SOD1 -251AG is associated with obesity independent of the presence of diabetes or dyslipidemia. Mutated obese carries of SOD1 -251, SOD2 47 and CAT -262 are associated with a higher distribution of fat in comparison with obese wild-type carriers. |
| Databáze: | OpenAIRE |
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