Neuroinflammation PET imaging of the translocator protein (TSPO) in Alzheimer's disease: An update

Autor:	Dominique Gouilly, Laure Saint‐Aubert, Maria‐Joao Ribeiro, Anne‐Sophie Salabert, Clovis Tauber, Patrice Péran, Nicolas Arlicot, Jérémie Pariente, Pierre Payoux
Rok vydání:	2022
Předmět:	Receptors GABA Alzheimer Disease Positron-Emission Tomography General Neuroscience Neuroinflammatory Diseases Brain Humans Microglia Carrier Proteins
Zdroj:	European Journal of Neuroscience. 55:1322-1343
ISSN:	1460-9568 0953-816X
Popis:	Neuroinflammation is a significant contributor to Alzheimer's disease (AD). Until now, PET imaging of the translocator protein (TSPO) has been widely used to depict the neuroimmune endophenotype of AD. The aim of this review was to provide an update to the results from 2018 and to advance the characterization of the biological basis of TSPO imaging in AD by re-examining TSPO function and expression and the methodological aspects of interest. Although the biological basis of the TSPO PET signal is obviously related to microglia and astrocytes in AD, the observed process remains uncertain and might not be directly related to neuroinflammation. Further studies are required to re-examine the cellular significance underlying a variation in the PET signal in AD.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d8ebd95264422cd0a890ee3383921f0 https://doi.org/10.1111/ejn.15613 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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