Effects of low-sodium, high-potassium dietary intake on cochlear lateral wall Na+,K(+)-ATPase
| Autor: | W.-J. F. Ten Cate, Kyle E. Rarey, Lisa M. Curtis |
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| Rok vydání: | 1994 |
| Předmět: |
Male
medicine.medical_specialty Potassium Sodium chemistry.chemical_element Enzyme-Linked Immunosorbent Assay Spironolactone chemistry.chemical_compound Internal medicine medicine Animals Na+/K+-ATPase Aldosterone business.industry Antagonist Potassium Dietary Stria Vascularis Sodium Dietary General Medicine Cochlear Duct Diet Sodium-Restricted Cochlea Rats Endocrinology Otorhinolaryngology chemistry Spiral ligament Sodium-Potassium-Exchanging ATPase business Low sodium |
| Zdroj: | European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery. 251(1) |
| ISSN: | 0937-4477 |
| Popis: | The effect of a low Na+, high K+ diet on Na+,K(+)-ATPase levels in cochlear lateral wall tissues was investigated in laboratory rats by using an enzyme-linked immunosorbent assay. The low Na+, high K+ diet induced high aldosterone plasma levels in the animals as well as changes in plasma cation levels. Animals that received a low Na+, high K+ diet demonstrated a statistically significant (97%) increase in Na+,K(+)-ATPase levels in the stria vascularis when compared to animals that received a control diet. This increase in strial Na+,K(+)-ATPase levels was blocked only 70% by administration of the aldosterone antagonist, spironolactone. Findings therefore indicate that strial Na+,K(+)-ATPase may be modulated by both aldosterone and Na+,K+ plasma levels. Na+,K(+)-ATPase levels in the spiral ligament were not affected by the experimental treatment. These findings suggest that spiral ligament Na+,K(+)-ATPase levels may be regulated by factors other than aldosterone and Na+,K+ plasma levels. This study provides further insight into the mechanisms of the beneficial effects of salt restriction and potassium loading in patients with Méniére's disease. |
| Databáze: | OpenAIRE |
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