The Effect of Cranial Irradiation on Blood-Brain Barrier Permeability to Methotrexate
| Autor: | Margaret Leahy, R. S. Seshadri, M. S. Rice, R. Ellis, R. G. Ryall |
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| Rok vydání: | 1979 |
| Předmět: |
Adult
Male musculoskeletal diseases Adolescent Lymphoma Central nervous system Pharmacology Asymptomatic Cerebrospinal fluid Cranial Irradiation medicine Humans Child Brain Neoplasms business.industry Brain Middle Aged medicine.disease Leukemia Lymphoid Leukemia Methotrexate medicine.anatomical_structure Blood-Brain Barrier Permeability (electromagnetism) Child Preschool Anesthesia Pediatrics Perinatology and Child Health Female medicine.symptom business medicine.drug |
| Zdroj: | Journal of Paediatrics and Child Health. 15:184-186 |
| ISSN: | 1440-1754 1034-4810 |
| Popis: | Seshadri, R. S., Ryall, R. G., Rice, M. S., Leahy, Margaret, and Ellis, R. (1979). Aust. Paediatr. J., 15, 184–186. The Effect of cranial irradiation on blood-brain barrier permeability to methotrexate. Methotrexate (MTX) was given orally (30 mg/m2) to 14 patients with leukaemia/lymphoma before and soon after cranial irradiation (Cl). The MTX levels in plasma and cerebrospinal fluid were measured three hours after the administration of MTX. Markedly increased blood-brain barrier (BBB) permeability of MTX was found in both asymptomatic and symptomatic patients with central nervous system (CNS) disease even before Cl. Successful treatment of the CNS disease decreased the BBB permeability to MTX. Cl per se did not increase the BBB permeability. |
| Databáze: | OpenAIRE |
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