Statin therapy and inflammation in patients with diabetes treated with high dose aspirin
| Autor: | Jalaj Garg, Denny Mathew, Rahul Chaudhary, Kevin P. Bliden, Paul A. Gurbel, Martin G. Gesheff, Peter P. Toth, Udaya S. Tantry, Shachi Pandya, Christopher J. Franzese, Nafees Mohammed |
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| Rok vydání: | 2016 |
| Předmět: |
Male
Cardiac Catheterization medicine.medical_specialty Statin medicine.drug_class Lipoproteins Endocrinology Diabetes and Metabolism Thrombogenicity 030209 endocrinology & metabolism Coronary Artery Disease 030204 cardiovascular system & hematology Gastroenterology Coronary artery disease 03 medical and health sciences 0302 clinical medicine Endocrinology Fibrinolytic Agents Diabetes mellitus Internal medicine Diabetes Mellitus Internal Medicine medicine Humans cardiovascular diseases Aged Inflammation Aspirin medicine.diagnostic_test business.industry Middle Aged medicine.disease Lipids Thromboxane B2 Female lipids (amino acids peptides and proteins) Density gradient ultracentrifugation Hydroxymethylglutaryl-CoA Reductase Inhibitors Lipid profile business Fibrinolytic agent medicine.drug |
| Zdroj: | Journal of Diabetes and its Complications. 30:1365-1370 |
| ISSN: | 1056-8727 |
| DOI: | 10.1016/j.jdiacomp.2016.05.002 |
| Popis: | Statin and aspirin form the therapeutic cornerstone in patients with coronary artery disease (CAD) and diabetes. Little is known about relationship of statins with blood thrombogenicity and inflammation in these patients.Two hundred nine consecutive patients with diabetes and suspected CAD undergoing elective cardiac catheterization were divided in groups based on statin treatment in the Multi-Analyte, Thrombogenic, and Genetic Markers Atherosclerosis study. Urinary 11-dehydrothromboxane B2 (11-dh-TxB2), lipid profile and oxLDL/β2GPI were measured by AspirinWorks™ ELISA assay, vertical density gradient ultracentrifugation and immunoassay respectively. Thrombelastography, and ADP- and collagen-induced light transmittance aggregometry assessed thrombogenicity. CAD was classified as none/minor [20% diameter stenosis (DS)], moderate (20-75% DS), or severe (75% DS).Severe, moderate, and no CAD was observed in 66, 19, and 15% of patients respectively. Patients on statins had significantly lower 11-dh-TxB2, collagen-induced aggregation, total cholesterol, total LDL, LDL3, oxidized-LDL, Apo B100, and ApoB100/A1 ratio (p0.01 for all). Statin therapy demonstrated a lower proportion of patients with high urinary 11-dh-TxB2 (1500pg 11-dh-TxB2/mg creatinine) (25 vs. 57%, p=0.01).Statins along with aspirin, confers additional anti-inflammatory and antithrombotic effect in diabetics with CAD. Urinary 11-dh-TxB2 may be a useful biomarker for personalizing statin therapy. |
| Databáze: | OpenAIRE |
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