Hepatocyte growth factor reduces CXCL10 expression in keratinocytes
| Autor: | Kenjiro Bandow, Tetsuya Matsuguchi, Joji Kusuyama, Kyoko Kakimoto, Tomokazu Ohnishi, Takuro Kanekura, Mitsuhiro Hisadome |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Keratinocytes
Vascular Endothelial Growth Factor A 0301 basic medicine Chemokine MAP Kinase Signaling System Angiogenesis Biophysics Dermatology Biochemistry Cell Line Mice 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Structural Biology Genetics medicine Animals Humans CXCL10 Molecular Biology integumentary system biology Hepatocyte Growth Factor Tumor Necrosis Factor-alpha Cell Biology Chemokine CXCL10 Vascular endothelial growth factor HaCaT Vascular endothelial growth factor A 030104 developmental biology Gene Expression Regulation chemistry 030220 oncology & carcinogenesis Immunology Cancer research biology.protein Hepatocyte growth factor Wound healing medicine.drug |
| Zdroj: | FEBS Letters. 590:3595-3605 |
| ISSN: | 0014-5793 |
| DOI: | 10.1002/1873-3468.12452 |
| Popis: | Keratinocytes secrete vascular endothelial growth factor (VEGF) and angioregulatory chemokines during cutaneous wound healing. Hepatocyte growth factor (HGF) promotes skin re-epithelialization by increasing VEGF expression in keratinocytes. Here, we investigated the regulatory roles of HGF in the expression of genes encoding angiogenic and angiostatic chemokines in keratinocytes and found that HGF specifically inhibits mRNA expression of the angiostatic chemokine CXCL10 in both mouse primary keratinocytes and in the human keratinocyte cell line HaCaT through the MEK/ERK cascade. Furthermore, HGF inhibited tumor necrosis factor-α-induced CXCL10 expression at both mRNA and protein levels in HaCaT cells. Thus, HGF may orchestrate angiogenesis in wounded skin by modulating both VEGF and CXCL10 expression in keratinocytes. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text