Phosphotungstic acid as a novel acidic catalyst for carbohydrate protection and glycosylation
| Autor: | Hsin-Ru Wu, Chih-Hsiang Liao, Po-Hsun Huang, Arumugam Sankar, Yi-Jyun Lin, Shen-Shen Wu, Shun-Yuan Luo, Jyun-Siao Chen |
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| Rok vydání: | 2019 |
| Předmět: |
Glycosylation
General Chemical Engineering Acetal Regioselectivity 02 engineering and technology General Chemistry Carbohydrate 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences 0104 chemical sciences Catalysis chemistry.chemical_compound chemistry Organic reaction Homogeneous Organic chemistry Phosphotungstic acid 0210 nano-technology |
| Zdroj: | RSC Advances. 9:33853-33862 |
| ISSN: | 2046-2069 |
| Popis: | This work demonstrates the utilization of phosphotungstic acid (PTA) as a novel acidic catalyst for carbohydrate reactions, such as per-O-acetylation, regioselective O-4,6 benzylidene acetal formation, regioselective O-4 ring-opening, and glycosylation. These reactions are basic and salient during the synthesis of carbohydrate-based bioactive oligomers. Phosphotungstic acid's high acidity and eco-friendly character make it a tempting alternative to corrosive homogeneous acids. The various homogenous acid catalysts were replaced by the phosphotungstic acid solely for different carbohydrate reactions. It can be widely used as a catalyst for organic reactions as it is thermally stable and easy to handle. In our work, the reactions are operated smoothly under ambient conditions; the temperature varies from 0 °C to room temperature. Good to excellent yields were obtained in all four kinds of reactions. |
| Databáze: | OpenAIRE |
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