Carbohydrate PEGylation, an approach to improve pharmacological potency
| Autor: | Rosalía Agusti, M. Eugenia Giorgi, Rosa M. de Lederkremer |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
conjugates
Glycan carbohydrates Polyethylene glycol Review lcsh:QD241-441 purl.org/becyt/ford/1 [https] chemistry.chemical_compound glycoPEGylation lcsh:Organic chemistry In vivo PEG ratio purl.org/becyt/ford/1.4 [https] lcsh:Science biology Chemistry Organic Chemistry Ciencias Químicas Combinatorial chemistry Bioavailability Sialic acid multivalent PEGylation Química Orgánica multivalent glycosystems Biochemistry Covalent bond biology.protein PEGylation lcsh:Q bioavailability CIENCIAS NATURALES Y EXACTAS |
| Zdroj: | Beilstein Journal of Organic Chemistry CONICET Digital (CONICET) Consejo Nacional de Investigaciones Científicas y Técnicas instacron:CONICET Beilstein Journal of Organic Chemistry, Vol 10, Iss 1, Pp 1433-1444 (2014) |
| ISSN: | 1860-5397 |
| Popis: | Conjugation with polyethylene glycol (PEG), known as PEGylation, has been widely used to improve the bioavailability of proteins and low molecular weight drugs. The covalent conjugation of PEG to the carbohydrate moiety of a protein has been mainly used to enhance the pharmacokinetic properties of the attached protein while yielding a more defined product. Thus, glycoPEGylation was successfully applied to the introduction of a PEGylated sialic acid to a preexisting or enzymatically linked glycan in a protein. Carbohydrates are now recognized as playing an important role in host–pathogen interactions in protozoal, bacterial and viral infections and are consequently candidates for chemotherapy. The short in vivo half-life of low molecular weight glycans hampered their use but methods for the covalent attachment of PEG have been less exploited. In this review, information on the preparation and application of PEG-carbohydrates, in particular multiarm PEGylation, is presented. Fil: Giorgi, María Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Centro de Investigaciones en Hidratos de Carbono; Argentina Fil: Agusti, Rosalia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Centro de Investigaciones en Hidratos de Carbono; Argentina Fil: Muchnik, Rosa. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Centro de Investigaciones en Hidratos de Carbono; Argentina |
| Databáze: | OpenAIRE |
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