Who Regulates Whom? An Overview of RNA Granules and Viral Infections
| Autor: | Fernando Valiente-Echeverría, Natalia Poblete-Durán, Yara Prades-Pérez, Ricardo Soto-Rifo, Jorge Vera-Otarola |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
translation control
0301 basic medicine stress granules viruses lcsh:QR1-502 Review Biology Cytoplasmic Granules lcsh:Microbiology Fight-or-flight response 03 medical and health sciences Stress granule Stress Physiological Virology P-bodies Protein biosynthesis Ribonucleoprotein 030102 biochemistry & molecular biology RNA granules RNA Molecular biology anti-viral host immune response Yeast Cell biology 030104 developmental biology Infectious Diseases Viral replication Protein Biosynthesis Host-Pathogen Interactions Viruses RNA Viral |
| Zdroj: | Viruses Viruses, Vol 8, Iss 7, p 180 (2016) |
| ISSN: | 1999-4915 |
| DOI: | 10.3390/v8070180 |
| Popis: | After viral infection, host cells respond by mounting an anti-viral stress response in order to create a hostile atmosphere for viral replication, leading to the shut-off of mRNA translation (protein synthesis) and the assembly of RNA granules. Two of these RNA granules have been well characterized in yeast and mammalian cells, stress granules (SGs), which are translationally silent sites of RNA triage and processing bodies (PBs), which are involved in mRNA degradation. This review discusses the role of these RNA granules in the evasion of anti-viral stress responses through virus-induced remodeling of cellular ribonucleoproteins (RNPs). |
| Databáze: | OpenAIRE |
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