Cytogenetic analysis of carboplatin resistance in early-stage epithelial ovarian carcinoma
| Autor: | György Horvath, Khalil Helou, Lovisa Österberg, Kristina Levan, Karolina Partheen |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Adult
Cancer Research endocrine system diseases Antineoplastic Agents Drug resistance Biology Carboplatin chemistry.chemical_compound Ovarian carcinoma Genetics medicine Humans Neoplasms Glandular and Epithelial Stage (cooking) Molecular Biology Aged Cause of death Aged 80 and over Chromosome Aberrations Ovarian Neoplasms Standard treatment Nucleic Acid Hybridization Middle Aged medicine.disease Combined Modality Therapy female genital diseases and pregnancy complications chemistry Drug Resistance Neoplasm Cancer research Female Ovarian cancer Comparative genomic hybridization |
| Zdroj: | Cancer Genetics and Cytogenetics. 163:144-150 |
| ISSN: | 0165-4608 |
| DOI: | 10.1016/j.cancergencyto.2005.06.023 |
| Popis: | Ovarian carcinoma is the leading cause of death among women with gynecological malignancies in western Europe. The high mortality rate is largely due to drug resistance. It is thus essential to increase knowledge and understanding of the underlying mechanisms of chemotherapy resistance, which might be caused by changes in the tumor genome. After surgery, carboplatin is the standard treatment for patients with early-stage ovarian cancer. Using comparative genomic hybridization (CGH), we explored cytogenetic alterations in 63 early-stage epithelial ovarian tumors, comparing the aberration patterns in the carboplatin-resistant and carboplatin-sensitive tumors. Several chromosomal regions were more frequently altered in the resistant tumors; some of these differences were statistically significant. We also found differences in tumor histology. Gains of 1q, 5q14 approximately q23, and 13q21 approximately q32, and losses of 8p and 9q were associated with clinical carboplatin resistance. Also, differences were found between the primary resistant and the secondary resistant tumors. Our findings demonstrate biologic observations of clinical drug resistance and specifically reveal chromosomal regions of interest for platinum resistance. |
| Databáze: | OpenAIRE |
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