Temporal Clinical Chemistry and Microscopic Renal Effects Following Acute Uranyl Acetate Exposure
| Autor: | Sandra Hancock, Lynette Tobias, Marion Ehrich, Bernard S. Jortner, David S. Barber, Jonathan Hinckley, Ellen M. Binder, Kurt L. Zimmerman |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Male
medicine.medical_specialty 040301 veterinary sciences Serum albumin Uranyl acetate Hematocrit Kidney Toxicology 030226 pharmacology & pharmacy Blood Urea Nitrogen Pathology and Forensic Medicine Nephrotoxicity Rats Sprague-Dawley 0403 veterinary science 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Corticosterone Internal medicine Organometallic Compounds medicine Animals Molecular Biology Acute tubular necrosis Dose-Response Relationship Drug medicine.diagnostic_test biology 04 agricultural and veterinary sciences Cell Biology medicine.disease Renal histology Rats Endocrinology medicine.anatomical_structure chemistry biology.protein Uranium |
| Zdroj: | Toxicologic Pathology. 35:1000-1009 |
| ISSN: | 1533-1601 0192-6233 |
| DOI: | 10.1080/01926230701748446 |
| Popis: | Military use of depleted uranium (DU) has renewed interest in the toxicology of this metal. In this study, the nephrotoxicity of single exposure DU was assessed with and without pre-exposure stress. Adult male Sprague–Dawley rats (n = 288) were administered a single IM dose of 0, 0.1, 0.3 or 1.0 mg/kg DU. Corticosterone concentrations (ng/ml, mean ± SD) were 763.65 ± 130.94 and 189.80 ± 90.81 for swim stressed and unstressed rats. Serum and kidney uranium concentration, hematocrit, chemistry, and renal histology were assessed on sacrifice days 1, 3, 7 and 30 post-DU-dosing. Dose related increases in serum and kidney uranium were noted. DU concentration peaked day 1 in the kidney and days 3–7, in the serum. Dose-related elevations of Cr and BUN concentrations were seen on days 3 and 7. A decline in serum albumin coincided with Cr and BUN suggesting protein losing nephropathy. Dose related acute tubular necrosis and proliferative glomulonephritis were seen. Tubular regeneration in low dose rats was almost complete by day 30. High dose rats had extensive tubular necrosis and delayed regeneration with focal residual chronic interstitial nephritis and cortical scarring. Glomular changes were reversed in all treatment groups by day 30. Stress exposure had no impact on any measured renal parameter. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|