If I do A, B will happen: Dissecting circuits detecting causal relations between actions and outcomes in marmoset prefrontal cortex
| Autor: | Matthew V. Chafee |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
contingency degradation
Prefrontal Cortex ventromedial prefrontal cortex Gyrus Cinguli Article common marmoset biology.animal medicine Animals Humans Gyrus cinguli habits Prefrontal cortex goal-directed behavior Neurons biology General Neuroscience Causal relations caudate nucleus Marmoset Callithrix biology.organism_classification obsessive-compulsive disorder anterior cingulate cortex medicine.anatomical_structure nervous system Orbitofrontal cortex Neuron orbitofrontal cortex Psychology Neuroscience |
| Zdroj: | Neuron |
| ISSN: | 0896-6273 |
| Popis: | Summary Impaired detection of causal relationships between actions and their outcomes can lead to maladaptive behavior. However, causal roles of specific prefrontal cortex (PFC) sub-regions and the caudate nucleus in mediating such relationships in primates are unclear. We inactivated and overactivated five PFC sub-regions, reversibly and pharmacologically: areas 24 (perigenual anterior cingulate cortex), 32 (medial PFC), 11 (anterior orbitofrontal cortex, OFC), 14 (rostral ventromedial PFC/medial OFC), and 14-25 (caudal ventromedial PFC) and the anteromedial caudate to examine their role in expressing learned action-outcome contingencies using a contingency degradation paradigm in marmoset monkeys. Area 24 or caudate inactivation impaired the response to contingency change, while area 11 inactivation enhanced it, and inactivation of areas 14, 32, or 14-25 had no effect. Overactivation of areas 11 and 24 impaired this response. These findings demonstrate the distinct roles of PFC sub-regions in goal-directed behavior and illuminate the candidate neurobehavioral substrates of psychiatric disorders, including obsessive-compulsive disorder. Highlights • Monkey pgACC-24 is necessary for detecting causal control of actions over outcomes • Its projection target in the caudate nucleus is also implicated • Three other subregions of the ventromedial prefrontal cortex are not necessary • Anterior OFC-11 may mediate Pavlovian influences on goal-directed behavior Duan et al. provide causal evidence in non-human primates that only PFC sub-region pgACC-24 and its target region in the caudate nucleus, but not mPFC-32, anterior OFC-11, rostral vmPFC-14, or caudal vmPFC-14-25, are critical for adapting instrumental responding following degradation of action-outcome contingencies in control of goal-directed behavior. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|